Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

Jie Yu Chuang; Kirstie J. Whitaker; Graham K. Murray; Rebecca Elliott; Cindy C. Hagan; Julia M.E. Graham; Cinly Ooi; Roger Tait; Rosemary J. Holt; Adrienne O. Van Nieuwenhuizen; Shirley Reynolds; Paul O. Wilkinson; Edward T. Bullmore; Belinda R. Lennox; Barbara J. Sahakian; Ian Goodyer; John Suckling

doi:10.1016/j.jad.2015.09.008

Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

Jie Yu Chuang^*, Kirstie J. Whitaker, Graham K. Murray, Rebecca Elliott, Cindy C. Hagan, Julia M.E. Graham, Cinly Ooi, Roger Tait, Rosemary J. Holt, Adrienne O. Van Nieuwenhuizen, Shirley Reynolds, Paul O. Wilkinson, Edward T. Bullmore, Belinda R. Lennox, Barbara J. Sahakian, Ian Goodyer, John Suckling

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

Original language	English
Pages (from-to)	54-61
Number of pages	8
Journal	Journal of Affective Disorders
Volume	189
DOIs	https://doi.org/10.1016/j.jad.2015.09.008
Publication status	Published (VoR) - 1 Jan 2016

Funding

The study was funded by the Medial Research Council (grant: G0802226). The IMPACT clinical trial was funded by the NHS Health Technology Assessment (HTA) Programme, Central Manchester and Manchester Children's University Hospitals NHS Trust, and the Cambridge and Peterborough Mental Health Trust. Additional support was provided by the jointly funded Medical Research Council/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. We appreciate technical help from Dr. Peter Watson, Mr. Andrew Jahn, Dr. Gonzalo Arrondo, Dr. Jeanette Mumford, Dr. Anderson M. Winkler, Dr. Zheng Ye, and Dr. Stuart Rankin. This work was performed using the Darwin Supercomputer of the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/), provided by Dell Inc. using Strategic Research Infrastructure Funding from the Higher Education Funding Council for England and funding from the Science and Technology Facilities Council. Professor Sahakian reports personal fees from Cambridge Cognition, personal fees and other from Lundbeck, personal fees from Servier, grants from J&J Janssen, other from Otsuka, personal fees from Peak (Brainbow), outside the submitted work; Professor Bullmore works half-time for the Univeristy of Cambridge and half-time for GlaxoSmithKline. He holds stock in GlaxoSmithKline. Professor Goodyer reports personal fees from Lundbeck and holds grants from the Wellcome Trust and the Friends of Peterhouse Charity and NIHR-HTA. Dr. Wilkinson reports grants from MRC during the conduct of the study; personal fees from Lundbeck, personal fees from Takeda, outside the submitted work; and acts as a supervisor and trainer for interpersonal psychotherapy.

Keywords

Adolescent depression
Cognitive behaviour therapy
Functional magnetic resonance imaging
Positive stimuli

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10.1016/j.jad.2015.09.008

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Chuang, J. Y., Whitaker, K. J., Murray, G. K., Elliott, R., Hagan, C. C., Graham, J. M. E., Ooi, C., Tait, R., Holt, R. J., Van Nieuwenhuizen, A. O., Reynolds, S., Wilkinson, P. O., Bullmore, E. T., Lennox, B. R., Sahakian, B. J., Goodyer, I., & Suckling, J. (2016). Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents. Journal of Affective Disorders, 189, 54-61. https://doi.org/10.1016/j.jad.2015.09.008

@article{23068526118045b7aa68e1c8ca175786,

title = "Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents",

keywords = "Adolescent depression, Cognitive behaviour therapy, Functional magnetic resonance imaging, Positive stimuli",

author = "Chuang, \{Jie Yu\} and Whitaker, \{Kirstie J.\} and Murray, \{Graham K.\} and Rebecca Elliott and Hagan, \{Cindy C.\} and Graham, \{Julia M.E.\} and Cinly Ooi and Roger Tait and Holt, \{Rosemary J.\} and \{Van Nieuwenhuizen\}, \{Adrienne O.\} and Shirley Reynolds and Wilkinson, \{Paul O.\} and Bullmore, \{Edward T.\} and Lennox, \{Belinda R.\} and Sahakian, \{Barbara J.\} and Ian Goodyer and John Suckling",

note = "Funding Information: The study was funded by the Medial Research Council (grant: G0802226). The IMPACT clinical trial was funded by the NHS Health Technology Assessment (HTA) Programme, Central Manchester and Manchester Children's University Hospitals NHS Trust, and the Cambridge and Peterborough Mental Health Trust. Additional support was provided by the jointly funded Medical Research Council/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. Funding Information: We appreciate technical help from Dr. Peter Watson, Mr. Andrew Jahn, Dr. Gonzalo Arrondo, Dr. Jeanette Mumford, Dr. Anderson M. Winkler, Dr. Zheng Ye, and Dr. Stuart Rankin. This work was performed using the Darwin Supercomputer of the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/), provided by Dell Inc. using Strategic Research Infrastructure Funding from the Higher Education Funding Council for England and funding from the Science and Technology Facilities Council. Funding Information: Professor Sahakian reports personal fees from Cambridge Cognition, personal fees and other from Lundbeck, personal fees from Servier, grants from J\&J Janssen, other from Otsuka, personal fees from Peak (Brainbow), outside the submitted work; Professor Bullmore works half-time for the Univeristy of Cambridge and half-time for GlaxoSmithKline. He holds stock in GlaxoSmithKline. Professor Goodyer reports personal fees from Lundbeck and holds grants from the Wellcome Trust and the Friends of Peterhouse Charity and NIHR-HTA. Dr. Wilkinson reports grants from MRC during the conduct of the study; personal fees from Lundbeck, personal fees from Takeda, outside the submitted work; and acts as a supervisor and trainer for interpersonal psychotherapy. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.jad.2015.09.008",

language = "English",

volume = "189",

pages = "54--61",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

Chuang, JY, Whitaker, KJ, Murray, GK, Elliott, R, Hagan, CC, Graham, JME, Ooi, C, Tait, R, Holt, RJ, Van Nieuwenhuizen, AO, Reynolds, S, Wilkinson, PO, Bullmore, ET, Lennox, BR, Sahakian, BJ, Goodyer, I & Suckling, J 2016, 'Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents', Journal of Affective Disorders, vol. 189, pp. 54-61. https://doi.org/10.1016/j.jad.2015.09.008

TY - JOUR

T1 - Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

AU - Chuang, Jie Yu

AU - Whitaker, Kirstie J.

AU - Murray, Graham K.

AU - Elliott, Rebecca

AU - Hagan, Cindy C.

AU - Graham, Julia M.E.

AU - Ooi, Cinly

AU - Tait, Roger

AU - Holt, Rosemary J.

AU - Van Nieuwenhuizen, Adrienne O.

AU - Reynolds, Shirley

AU - Wilkinson, Paul O.

AU - Bullmore, Edward T.

AU - Lennox, Belinda R.

AU - Sahakian, Barbara J.

AU - Goodyer, Ian

AU - Suckling, John

N1 - Funding Information: The study was funded by the Medial Research Council (grant: G0802226). The IMPACT clinical trial was funded by the NHS Health Technology Assessment (HTA) Programme, Central Manchester and Manchester Children's University Hospitals NHS Trust, and the Cambridge and Peterborough Mental Health Trust. Additional support was provided by the jointly funded Medical Research Council/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. Funding Information: We appreciate technical help from Dr. Peter Watson, Mr. Andrew Jahn, Dr. Gonzalo Arrondo, Dr. Jeanette Mumford, Dr. Anderson M. Winkler, Dr. Zheng Ye, and Dr. Stuart Rankin. This work was performed using the Darwin Supercomputer of the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/), provided by Dell Inc. using Strategic Research Infrastructure Funding from the Higher Education Funding Council for England and funding from the Science and Technology Facilities Council. Funding Information: Professor Sahakian reports personal fees from Cambridge Cognition, personal fees and other from Lundbeck, personal fees from Servier, grants from J&J Janssen, other from Otsuka, personal fees from Peak (Brainbow), outside the submitted work; Professor Bullmore works half-time for the Univeristy of Cambridge and half-time for GlaxoSmithKline. He holds stock in GlaxoSmithKline. Professor Goodyer reports personal fees from Lundbeck and holds grants from the Wellcome Trust and the Friends of Peterhouse Charity and NIHR-HTA. Dr. Wilkinson reports grants from MRC during the conduct of the study; personal fees from Lundbeck, personal fees from Takeda, outside the submitted work; and acts as a supervisor and trainer for interpersonal psychotherapy. Publisher Copyright: © 2015 The Authors.

PY - 2016/1/1

Y1 - 2016/1/1

KW - Adolescent depression

KW - Cognitive behaviour therapy

KW - Functional magnetic resonance imaging

KW - Positive stimuli

UR - https://www.scopus.com/pages/publications/84942342221

UR - https://www.scopus.com/inward/citedby.url?scp=84942342221&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2015.09.008

DO - 10.1016/j.jad.2015.09.008

M3 - Article

C2 - 26406969

AN - SCOPUS:84942342221

SN - 0165-0327

VL - 189

SP - 54

EP - 61

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

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