Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance

Athlome Project Consortium

doi:10.1152/physiolgenomics.00105.2015

Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance

Athlome Project Consortium

Research output: Contribution to journal › Review article › peer-review

99 Citations (SciVal)

Original language	English
Pages (from-to)	183-190
Number of pages	8
Journal	Physiological Genomics
Volume	48
Issue number	3
DOIs	https://doi.org/10.1152/physiolgenomics.00105.2015
Publication status	Published (VoR) - 1 Mar 2016

Keywords

Genetics
Performance
Sports genomics

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10.1152/physiolgenomics.00105.2015

Cite this

@article{74199eeee5b64d78bd9cffb46f38c3d2,

title = "Athlome project consortium: A concerted effort to discover genomic and other {"}omic{"} markers of athletic performance",

keywords = "Genetics, Performance, Sports genomics",

author = "{Athlome Project Consortium} and Pitsiladis, {Yannis P.} and Masashi Tanaka and Nir Eynon and Claude Bouchard and North, {Kathryn N.} and Williams, {Alun G.} and Malcolm Collins and Moran, {Colin N.} and Britton, {Steven L.} and Noriyuki Fuku and Ashley, {Euan A.} and Vassilis Klissouras and Alejandro Lucia and Ahmetov, {Ildus I.} and {De Geus}, Eco and Mohammed Alsayrafi and Nick Webborn and Guan Wang and Bishop, {David J.} and Ioannis Papadimitriou and Xu Yan and Oren Tirosh and Jujiao Kuang and Tuomo Rankinen and Mark Sarzinsky and {Mikael Mattsson}, C. and Matthew Wheeler and Daryl Waggott and Byrne, {Nuala M.} and Artioli, {Guilherme G.} and Alison September and Michael Posthumus and {Van der Merwe}, Willem and Pawel Cieszczyk and Agata Leonska-Duniec and Krzysztof Ficek and Agnieszka Maciejewska-Karlowska and Marek Sawczuk and Marta Stepien-Slodkowska and Julian Feller and Paul Dijkstra and Chmutov, {Aleksandr M.} and Dyatlov, {Dmitry A.} and Orekhov, {Evgeniy F.} and Pushkareva, {Yuliya E.} and Shvedkaya, {Irina A.} and Myosotis Massidda and Cal{\`o}, {Carla M.} and Day, {Stephen H.} and Hughes, {David C.}",

note = "Funding Information: Eastern Europe population studies (The Russian and Belarusian cohorts, GELAK, GELAV, GUAP) were supported by the grants from the Federal Agency for Physical Culture and Sport of the Russian Federation and the Ministry of Education and Science of the Russian Federation (contract number 02.522.11.2004), the Federal Medical-Biological Agency of the Russian Federation ({"}Sportgen project{"}), Republic of Belarus (State Program of Development of Physical Culture and Sports for 2011-2015), and Royal Society International joint project grant from the UK (code F-90014). GELAV (Epigenetics of Lithuanian Athletes from Vilnius) project was developed by the Lithuanian National Olympic Committee and Lithuanian Olympic Sports Centre, while actual research was carried out at the Vilnius University, where Lithuanian athletes DNA samples are stored. We thank Prof. Vaidutis Ku?inskas, Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University, Lithuania, for providing ideas and support for accessing the control samples. ELITE is supported by SAP/Stanford Sequencing Initiative and Women?s Heart Health at Stanford. GAMES was partially funded by the Prince Faisal Prize awarded to C. Bouchard, T. Rankinen, M. Sarzynski, and B. Wolfarth. CB is partially funded by the John W. Barton Jr. Chair in Genetics and Nutrition. The study in Russia was supported by a grant from the Federal Medical-Biological Agency ({"}Sportgen project{"}), http://fmbaros.ru/en/fmba/infor/. The Spanish group is funded by C?tedra Real-Madrid Universidad Europea and Fondo de Investigaciones Sanitarias and Fondos Feder (Grant PI12/00914). This work in Japan was supported in part by grants from the programs Grants-in-Aid for Challenging Exploratory Research (24650414 to NF) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and by a Grants-in-aid for Scientific Research (KAKENHI) from the Ministry of Health, Labor, and Welfare of Japan (to MM). No specific funding for this work was received for the studies performed in Australia, Poland, Kenya, and Ethiopia. Gene SMART Study is partly supported by N. Eynon?s Australian Research Council Early Career Fellowship DE#140100864 and by the Victoria University Central Research Grant Scheme. GOINg is supported by funds from the National Research Foundation of South Africa and the Thembakazi Trust. J-HAP project was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (Grants 21680050, 11J04771, 24650414, 26882041, 15H03081, and 15K16467) and by MEXT-commissioned projects. NTR?s funding was obtained from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10- 020, 904-61-193, 480-04-004, 463-06-001, 451-04-034, 400v05-717, Addiction- 31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192, Center for Medical Systems Biology (CSMB, NWO Genomics), NBIC/ BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007). VU University?s Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam; the European Science Foundation (EU/QLRT-2001-01254), the European Community?s Seventh Framework Program (FP7/2007-2013), ENGAGE (HEALTH-F4-2007-201413); the European Research Council (ERC Advanced, 230374, ERC Starting Grant 284 167), Rutgers University Cell and DNA Repository (NIMH U24 MH-068457-06), the Avera Institute, Sioux Falls, SD (USA), and the National Institutes of Health (NIH, R01D0042157- 01A, MH-081802; R01 DK-092127-04, Grand Opportunity Grants 1RC2 MH-089951 and 1RC2 MH-089995). Computing was supported by BiG Grid, the Dutch e-Science Grid, which is financially supported by NWO. Super-athletes: Genes and Sweat is partly funded by Qatar National Research Foundation NPRP Grant (NPRP 7-272-1-041). POWERGENE GWAS genotyping in Jamaicans, African-Americans (the USA cohort) and Japanese was funded by JSPS KAKENHI (Grants 21680050 and 24650414). Rat models of exercise and health (LCR-HCR rat model) was funded by the NIH Office of Research Infrastructure Programs/OD Grant R24OD-010950 and by Grant R01DK-099034 (to LGK and SLB). We acknowledge the expert care of the rat colony provided by Molly Kalahar and Lori Heckenkamp. Contact: LGK [email protected] or SLB [email protected] for information on the LCR and HCR rats; these rat models are maintained as an international resource with support from the Department of Anesthesiology at the University of Michigan, Ann Arbor, MI. 1000 Athlomes Project is funded by KAKENHI (A)-15200051, (A)-22240072, (A)-25242062 from MEXT and JSPS. Publisher Copyright: {\textcopyright} 2016 the American Physiological Society.",

year = "2016",

month = mar,

day = "1",

doi = "10.1152/physiolgenomics.00105.2015",

language = "English",

volume = "48",

pages = "183--190",

journal = "Physiological Genomics",

issn = "1094-8341",

publisher = "American Physiological Society",

number = "3",

}

TY - JOUR

T1 - Athlome project consortium

T2 - A concerted effort to discover genomic and other "omic" markers of athletic performance

AU - Athlome Project Consortium

AU - Pitsiladis, Yannis P.

AU - Tanaka, Masashi

AU - Eynon, Nir

AU - Bouchard, Claude

AU - North, Kathryn N.

AU - Williams, Alun G.

AU - Collins, Malcolm

AU - Moran, Colin N.

AU - Britton, Steven L.

AU - Fuku, Noriyuki

AU - Ashley, Euan A.

AU - Klissouras, Vassilis

AU - Lucia, Alejandro

AU - Ahmetov, Ildus I.

AU - De Geus, Eco

AU - Alsayrafi, Mohammed

AU - Webborn, Nick

AU - Wang, Guan

AU - Bishop, David J.

AU - Papadimitriou, Ioannis

AU - Yan, Xu

AU - Tirosh, Oren

AU - Kuang, Jujiao

AU - Rankinen, Tuomo

AU - Sarzinsky, Mark

AU - Mikael Mattsson, C.

AU - Wheeler, Matthew

AU - Waggott, Daryl

AU - Byrne, Nuala M.

AU - Artioli, Guilherme G.

AU - September, Alison

AU - Posthumus, Michael

AU - Van der Merwe, Willem

AU - Cieszczyk, Pawel

AU - Leonska-Duniec, Agata

AU - Ficek, Krzysztof

AU - Maciejewska-Karlowska, Agnieszka

AU - Sawczuk, Marek

AU - Stepien-Slodkowska, Marta

AU - Feller, Julian

AU - Dijkstra, Paul

AU - Chmutov, Aleksandr M.

AU - Dyatlov, Dmitry A.

AU - Orekhov, Evgeniy F.

AU - Pushkareva, Yuliya E.

AU - Shvedkaya, Irina A.

AU - Massidda, Myosotis

AU - Calò, Carla M.

AU - Day, Stephen H.

AU - Hughes, David C.

N1 - Funding Information: Eastern Europe population studies (The Russian and Belarusian cohorts, GELAK, GELAV, GUAP) were supported by the grants from the Federal Agency for Physical Culture and Sport of the Russian Federation and the Ministry of Education and Science of the Russian Federation (contract number 02.522.11.2004), the Federal Medical-Biological Agency of the Russian Federation ("Sportgen project"), Republic of Belarus (State Program of Development of Physical Culture and Sports for 2011-2015), and Royal Society International joint project grant from the UK (code F-90014). GELAV (Epigenetics of Lithuanian Athletes from Vilnius) project was developed by the Lithuanian National Olympic Committee and Lithuanian Olympic Sports Centre, while actual research was carried out at the Vilnius University, where Lithuanian athletes DNA samples are stored. We thank Prof. Vaidutis Ku?inskas, Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University, Lithuania, for providing ideas and support for accessing the control samples. ELITE is supported by SAP/Stanford Sequencing Initiative and Women?s Heart Health at Stanford. GAMES was partially funded by the Prince Faisal Prize awarded to C. Bouchard, T. Rankinen, M. Sarzynski, and B. Wolfarth. CB is partially funded by the John W. Barton Jr. Chair in Genetics and Nutrition. The study in Russia was supported by a grant from the Federal Medical-Biological Agency ("Sportgen project"), http://fmbaros.ru/en/fmba/infor/. The Spanish group is funded by C?tedra Real-Madrid Universidad Europea and Fondo de Investigaciones Sanitarias and Fondos Feder (Grant PI12/00914). This work in Japan was supported in part by grants from the programs Grants-in-Aid for Challenging Exploratory Research (24650414 to NF) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and by a Grants-in-aid for Scientific Research (KAKENHI) from the Ministry of Health, Labor, and Welfare of Japan (to MM). No specific funding for this work was received for the studies performed in Australia, Poland, Kenya, and Ethiopia. Gene SMART Study is partly supported by N. Eynon?s Australian Research Council Early Career Fellowship DE#140100864 and by the Victoria University Central Research Grant Scheme. GOINg is supported by funds from the National Research Foundation of South Africa and the Thembakazi Trust. J-HAP project was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (Grants 21680050, 11J04771, 24650414, 26882041, 15H03081, and 15K16467) and by MEXT-commissioned projects. NTR?s funding was obtained from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10- 020, 904-61-193, 480-04-004, 463-06-001, 451-04-034, 400v05-717, Addiction- 31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192, Center for Medical Systems Biology (CSMB, NWO Genomics), NBIC/ BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007). VU University?s Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam; the European Science Foundation (EU/QLRT-2001-01254), the European Community?s Seventh Framework Program (FP7/2007-2013), ENGAGE (HEALTH-F4-2007-201413); the European Research Council (ERC Advanced, 230374, ERC Starting Grant 284 167), Rutgers University Cell and DNA Repository (NIMH U24 MH-068457-06), the Avera Institute, Sioux Falls, SD (USA), and the National Institutes of Health (NIH, R01D0042157- 01A, MH-081802; R01 DK-092127-04, Grand Opportunity Grants 1RC2 MH-089951 and 1RC2 MH-089995). Computing was supported by BiG Grid, the Dutch e-Science Grid, which is financially supported by NWO. Super-athletes: Genes and Sweat is partly funded by Qatar National Research Foundation NPRP Grant (NPRP 7-272-1-041). POWERGENE GWAS genotyping in Jamaicans, African-Americans (the USA cohort) and Japanese was funded by JSPS KAKENHI (Grants 21680050 and 24650414). Rat models of exercise and health (LCR-HCR rat model) was funded by the NIH Office of Research Infrastructure Programs/OD Grant R24OD-010950 and by Grant R01DK-099034 (to LGK and SLB). We acknowledge the expert care of the rat colony provided by Molly Kalahar and Lori Heckenkamp. Contact: LGK [email protected] or SLB [email protected] for information on the LCR and HCR rats; these rat models are maintained as an international resource with support from the Department of Anesthesiology at the University of Michigan, Ann Arbor, MI. 1000 Athlomes Project is funded by KAKENHI (A)-15200051, (A)-22240072, (A)-25242062 from MEXT and JSPS. Publisher Copyright: © 2016 the American Physiological Society.

PY - 2016/3/1

Y1 - 2016/3/1

KW - Genetics

KW - Performance

KW - Sports genomics

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U2 - 10.1152/physiolgenomics.00105.2015

DO - 10.1152/physiolgenomics.00105.2015

M3 - Review article

C2 - 26715623

AN - SCOPUS:84984853469

SN - 1094-8341

VL - 48

SP - 183

EP - 190

JO - Physiological Genomics

JF - Physiological Genomics

IS - 3

ER -

Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance

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