Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

Loukia G. Tsaprouni; Tsun Po Yang; Jordana Bell; Katherine J. Dick; Stavroula Kanoni; James Nisbet; Ana Viñuela; Elin Grundberg; Christopher P. Nelson; Eshwar Meduri; Alfonso Buil; Francois Cambien; Christian Hengstenberg; Jeanette Erdmann; Heribert Schunkert; Alison H. Goodall; Willem H. Ouwehand; Emmanouil Dermitzakis; Tim D. Spector; Nilesh J. Samani; Panos Deloukas

doi:10.4161/15592294.2014.969637

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

Loukia G. Tsaprouni
, Tsun Po Yang
, Jordana Bell
, Katherine J. Dick
, Stavroula Kanoni
, James Nisbet
, Ana Viñuela
, Elin Grundberg
, Christopher P. Nelson
, Eshwar Meduri
, Alfonso Buil
, Francois Cambien
, Christian Hengstenberg
, Jeanette Erdmann
, Heribert Schunkert
, Alison H. Goodall
, Willem H. Ouwehand
, Emmanouil Dermitzakis
, Tim D. Spector
, Nilesh J. Samani

Panos Deloukas^*

^*Corresponding author for this work

Wellcome Sanger Institute
University of Bedfordshire
University of Cambridge
King's College London
University of Leicester
Glenfield Hospital
Queen Mary University of London
McGill University
University of Geneva
Sorbonne Université
Klinik und Poliklinik für Innere Medizin II
University of Lübeck
German Centre for Cardiovascular Research
NHS Blood and Transplant
King Abdulaziz University

Research output: Contribution to journal › Article › peer-review

273 Citations (SciVal)

Original language	English
Pages (from-to)	1382-1396
Number of pages	15
Journal	Epigenetics
Volume	9
Issue number	10
DOIs	https://doi.org/10.4161/15592294.2014.969637
Publication status	Published (VoR) - 2014

Funding

1Wellcome Trust Sanger Institute; Hinxton, Cambridge, UK; 2ISPAR; University of Bedfordshire; Bedfordshire, UK; 3MRC Cancer Unit; University of Cambridge; Cambridge, UK; 4Department of Twin Research and Genetic Epidemiology; King’s College London; London, UK; 5Department of Cardiovascular Sciences; University of Leicester Glenfield Hospital; Leicester, UK; 6NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital; Leicester, UK; 7William Harvey Research Institute; Barts and The London School of Medicine and Dentistry; Queen Mary University of London; London, UK; 8Department of Human Genetics; McGill University; McGill University and Genome Quebec Innovation Center; Montreal, Canada; 9Department of Genetic Medicine and Development and Institute for Genetics and Genomics in Geneva; University of Geneva Medical School; Geneva, Switzerland; 10Pierre and Marie Curie University and Medical School; Paris, France; 11Klinik und Poliklinik fu€r Innere Medizin II; Regensburg, Germany; 12Universit€at zu Lu€beck; Institut fu€r Integrative und ExperimentelleGenomik; Lu€beck, Germany; 13German Center for Cardiovascular Research; Munich, Germany; 14Department of Haematology; University of Cambridge and National Health Service (NHS) Blood and Transplant; Cambridge, UK; 15Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders (PACER-HD); King Abdulaziz University; Jeddah, Saudi Arabia

Keywords

CHRND
CPOX
DNA methylation
Epigenome-wide screen
Gene network
Smoking
metQTLs
rs2697768

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10.4161/15592294.2014.969637

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Tsaprouni, L. G., Yang, T. P., Bell, J., Dick, K. J., Kanoni, S., Nisbet, J., Viñuela, A., Grundberg, E., Nelson, C. P., Meduri, E., Buil, A., Cambien, F., Hengstenberg, C., Erdmann, J., Schunkert, H., Goodall, A. H., Ouwehand, W. H., Dermitzakis, E., Spector, T. D., ... Deloukas, P. (2014). Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics, 9(10), 1382-1396. https://doi.org/10.4161/15592294.2014.969637

@article{7430864d193745fcbd0a79bdd6590b48,

title = "Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation",

keywords = "CHRND, CPOX, DNA methylation, Epigenome-wide screen, Gene network, Smoking, metQTLs, rs2697768",

author = "Tsaprouni, \{Loukia G.\} and Yang, \{Tsun Po\} and Jordana Bell and Dick, \{Katherine J.\} and Stavroula Kanoni and James Nisbet and Ana Vi{\~n}uela and Elin Grundberg and Nelson, \{Christopher P.\} and Eshwar Meduri and Alfonso Buil and Francois Cambien and Christian Hengstenberg and Jeanette Erdmann and Heribert Schunkert and Goodall, \{Alison H.\} and Ouwehand, \{Willem H.\} and Emmanouil Dermitzakis and Spector, \{Tim D.\} and Samani, \{Nilesh J.\} and Panos Deloukas",

note = "Funding Information: 1Wellcome Trust Sanger Institute; Hinxton, Cambridge, UK; 2ISPAR; University of Bedfordshire; Bedfordshire, UK; 3MRC Cancer Unit; University of Cambridge; Cambridge, UK; 4Department of Twin Research and Genetic Epidemiology; King{\textquoteright}s College London; London, UK; 5Department of Cardiovascular Sciences; University of Leicester Glenfield Hospital; Leicester, UK; 6NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital; Leicester, UK; 7William Harvey Research Institute; Barts and The London School of Medicine and Dentistry; Queen Mary University of London; London, UK; 8Department of Human Genetics; McGill University; McGill University and Genome Quebec Innovation Center; Montreal, Canada; 9Department of Genetic Medicine and Development and Institute for Genetics and Genomics in Geneva; University of Geneva Medical School; Geneva, Switzerland; 10Pierre and Marie Curie University and Medical School; Paris, France; 11Klinik und Poliklinik fu€r Innere Medizin II; Regensburg, Germany; 12Universit€at zu Lu€beck; Institut fu€r Integrative und ExperimentelleGenomik; Lu€beck, Germany; 13German Center for Cardiovascular Research; Munich, Germany; 14Department of Haematology; University of Cambridge and National Health Service (NHS) Blood and Transplant; Cambridge, UK; 15Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders (PACER-HD); King Abdulaziz University; Jeddah, Saudi Arabia Publisher Copyright: {\textcopyright} 2014 Taylor \& Francis Group, LLC.",

year = "2014",

doi = "10.4161/15592294.2014.969637",

language = "English",

volume = "9",

pages = "1382--1396",

journal = "Epigenetics",

issn = "1559-2294",

publisher = "Taylor and Francis Group",

number = "10",

}

Tsaprouni, LG, Yang, TP, Bell, J, Dick, KJ, Kanoni, S, Nisbet, J, Viñuela, A, Grundberg, E, Nelson, CP, Meduri, E, Buil, A, Cambien, F, Hengstenberg, C, Erdmann, J, Schunkert, H, Goodall, AH, Ouwehand, WH, Dermitzakis, E, Spector, TD, Samani, NJ & Deloukas, P 2014, 'Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation', Epigenetics, vol. 9, no. 10, pp. 1382-1396. https://doi.org/10.4161/15592294.2014.969637

TY - JOUR

T1 - Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

AU - Tsaprouni, Loukia G.

AU - Yang, Tsun Po

AU - Bell, Jordana

AU - Dick, Katherine J.

AU - Kanoni, Stavroula

AU - Nisbet, James

AU - Viñuela, Ana

AU - Grundberg, Elin

AU - Nelson, Christopher P.

AU - Meduri, Eshwar

AU - Buil, Alfonso

AU - Cambien, Francois

AU - Hengstenberg, Christian

AU - Erdmann, Jeanette

AU - Schunkert, Heribert

AU - Goodall, Alison H.

AU - Ouwehand, Willem H.

AU - Dermitzakis, Emmanouil

AU - Spector, Tim D.

AU - Samani, Nilesh J.

AU - Deloukas, Panos

N1 - Funding Information: 1Wellcome Trust Sanger Institute; Hinxton, Cambridge, UK; 2ISPAR; University of Bedfordshire; Bedfordshire, UK; 3MRC Cancer Unit; University of Cambridge; Cambridge, UK; 4Department of Twin Research and Genetic Epidemiology; King’s College London; London, UK; 5Department of Cardiovascular Sciences; University of Leicester Glenfield Hospital; Leicester, UK; 6NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital; Leicester, UK; 7William Harvey Research Institute; Barts and The London School of Medicine and Dentistry; Queen Mary University of London; London, UK; 8Department of Human Genetics; McGill University; McGill University and Genome Quebec Innovation Center; Montreal, Canada; 9Department of Genetic Medicine and Development and Institute for Genetics and Genomics in Geneva; University of Geneva Medical School; Geneva, Switzerland; 10Pierre and Marie Curie University and Medical School; Paris, France; 11Klinik und Poliklinik fu€r Innere Medizin II; Regensburg, Germany; 12Universit€at zu Lu€beck; Institut fu€r Integrative und ExperimentelleGenomik; Lu€beck, Germany; 13German Center for Cardiovascular Research; Munich, Germany; 14Department of Haematology; University of Cambridge and National Health Service (NHS) Blood and Transplant; Cambridge, UK; 15Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders (PACER-HD); King Abdulaziz University; Jeddah, Saudi Arabia Publisher Copyright: © 2014 Taylor & Francis Group, LLC.

PY - 2014

Y1 - 2014

KW - CHRND

KW - CPOX

KW - DNA methylation

KW - Epigenome-wide screen

KW - Gene network

KW - Smoking

KW - metQTLs

KW - rs2697768

UR - https://www.scopus.com/pages/publications/84922021718

UR - https://www.scopus.com/pages/publications/84922021718#tab=citedBy

U2 - 10.4161/15592294.2014.969637

DO - 10.4161/15592294.2014.969637

M3 - Article

C2 - 25424692

AN - SCOPUS:84922021718

SN - 1559-2294

VL - 9

SP - 1382

EP - 1396

JO - Epigenetics

JF - Epigenetics

IS - 10

ER -

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

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Keywords

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