Cognitive behavioral therapy may have a rehabilitative, not normalizing, effect on functional connectivity in adolescent depression

L. M. Villa*, I. M. Goodyer, R. Tait, R. Kelvin, S. Reynolds, P. O. Wilkinson, J. Suckling

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    18 Citations (SciVal)
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalJournal of Affective Disorders
    Volume268
    DOIs
    Publication statusPublished (VoR) - 1 May 2020

    Funding

    The study was funded by the UK Medical Research Council (grant: G0802226), the National Institute for Health Research (NIHR) (grant: 06-05-01), financial support from the Department of Health, and the Behavioral and Clinical Neuroscience Institute (BCNI), University of Cambridge, the latter being jointly funded by the Medical Research Council G0802226 and the Wellcome Trust. Additional support was received from the Cambridge Biomedical Research centre. We are extremely grateful to all participants for their contribution to this work. We also thank the role of the Wolfson Brain Imaging centre, Cambridgeshire and Peterborough NHS Foundation Trust, Child and Adolescent Mental Health Services, Mental Health Research Network, IMPACT research assistants, IMPACT clinicians, and the IMPACT Consortium, without whom this study could not have taken place. Luca Villa is supported by the Oon Khye Beng Ch'hia Tsio Studentship from Downing College, University of Cambridge. Luca Villa, Professor Suckling, Dr. Wilkinson, Dr. Tait, and Professor Reynolds have no conflicts of interest to disclose. Professor Ian Goodyer has received consulting fees from Lundbeck Pharmaceuticals and is supported by a strategic award from the Wellcome Trust (095844/Z/11/Z). Dr. Raphael Kelvin has received consulting fees from Lundbeck Pharmaceuticals. We are extremely grateful to all participants for their contribution to this work. We also thank the role of the Wolfson Brain Imaging centre, Cambridgeshire and Peterborough NHS Foundation Trust, Child and Adolescent Mental Health Services, Mental Health Research Network, IMPACT research assistants, IMPACT clinicians, and the IMPACT Consortium, without whom this study could not have taken place. Luca Villa is supported by the Oon Khye Beng Ch'hia Tsio Studentship from Downing College, University of Cambridge. The study was funded by the UK Medical Research Council (grant: G0802226 ), the National Institute for Health Research (NIHR) (grant: 06-05-01 ), financial support from the Department of Health , and the Behavioral and Clinical Neuroscience Institute (BCNI), University of Cambridge, the latter being jointly funded by the Medical Research Council G0802226 and the Wellcome Trust. Additional support was received from the Cambridge Biomedical Research centre .

    Keywords

    • Adolescent depression
    • CBT
    • Cortical thickness
    • MRI
    • Resting-state functional connectivity
    • White matter volume

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