Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial

Isabelle L. Smith; Rachael Gilberts; Sarah Brown; Catherine Fernandez; Jane Nixon; Catherine Reynolds; Catherine Smith; John T. Lear; Lesley Sunderland; Cathy Green; Mark Goodfield; Fiona Cowdell; Philip Hampton; Amy Barker; Armando Vargas-Palacios; Sandy Tubeuf; Miriam Wittmann

doi:10.1136/bmjopen-2021-060029

Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial

Isabelle L. Smith^*, Rachael Gilberts, Sarah Brown, Catherine Fernandez, Jane Nixon, Catherine Reynolds, Catherine Smith, John T. Lear, Lesley Sunderland, Cathy Green, Mark Goodfield, Fiona Cowdell, Philip Hampton, Amy Barker, Armando Vargas-Palacios, Sandy Tubeuf, Miriam Wittmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

Original language	English
Article number	e060029
Journal	BMJ Open
Volume	12
Issue number	2
DOIs	https://doi.org/10.1136/bmjopen-2021-060029
Publication status	Published (VoR) - 23 Feb 2022

Funding

Funding This study was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (Project: 12/186/01). The trial grant application was supported by the Leeds Dermatology Patients Panel, patient members of the UKDCTN, and the Leeds Musculoskeletal Biomedical Research Unit patient and public advocacy group. Based on the feedback received, and in recognition to what is important to patients, we put a special emphasis on long term outcomes as well as on educational aspects in the trial design.

Keywords

dermatology
eczema
occupational dermatology
photodermatology

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10.1136/bmjopen-2021-060029

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Smith, I. L., Gilberts, R., Brown, S., Fernandez, C., Nixon, J., Reynolds, C., Smith, C., Lear, J. T., Sunderland, L., Green, C., Goodfield, M., Cowdell, F., Hampton, P., Barker, A., Vargas-Palacios, A., Tubeuf, S., & Wittmann, M. (2022). Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial. BMJ Open, 12(2), Article e060029. https://doi.org/10.1136/bmjopen-2021-060029

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title = "Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial",

keywords = "dermatology, eczema, occupational dermatology, photodermatology",

author = "Smith, \{Isabelle L.\} and Rachael Gilberts and Sarah Brown and Catherine Fernandez and Jane Nixon and Catherine Reynolds and Catherine Smith and Lear, \{John T.\} and Lesley Sunderland and Cathy Green and Mark Goodfield and Fiona Cowdell and Philip Hampton and Amy Barker and Armando Vargas-Palacios and Sandy Tubeuf and Miriam Wittmann",

note = "Funding Information: Funding This study was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (Project: 12/186/01). Funding Information: The trial grant application was supported by the Leeds Dermatology Patients Panel, patient members of the UKDCTN, and the Leeds Musculoskeletal Biomedical Research Unit patient and public advocacy group. Based on the feedback received, and in recognition to what is important to patients, we put a special emphasis on long term outcomes as well as on educational aspects in the trial design. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2022.",

year = "2022",

month = feb,

day = "23",

doi = "10.1136/bmjopen-2021-060029",

language = "English",

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Smith, IL, Gilberts, R, Brown, S, Fernandez, C, Nixon, J, Reynolds, C, Smith, C, Lear, JT, Sunderland, L, Green, C, Goodfield, M, Cowdell, F, Hampton, P, Barker, A, Vargas-Palacios, A, Tubeuf, S & Wittmann, M 2022, 'Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial', BMJ Open, vol. 12, no. 2, e060029. https://doi.org/10.1136/bmjopen-2021-060029

TY - JOUR

T1 - Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA)

T2 - study protocol for a randomised controlled trial

AU - Smith, Isabelle L.

AU - Gilberts, Rachael

AU - Brown, Sarah

AU - Fernandez, Catherine

AU - Nixon, Jane

AU - Reynolds, Catherine

AU - Smith, Catherine

AU - Lear, John T.

AU - Sunderland, Lesley

AU - Green, Cathy

AU - Goodfield, Mark

AU - Cowdell, Fiona

AU - Hampton, Philip

AU - Barker, Amy

AU - Vargas-Palacios, Armando

AU - Tubeuf, Sandy

AU - Wittmann, Miriam

N1 - Funding Information: Funding This study was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (Project: 12/186/01). Funding Information: The trial grant application was supported by the Leeds Dermatology Patients Panel, patient members of the UKDCTN, and the Leeds Musculoskeletal Biomedical Research Unit patient and public advocacy group. Based on the feedback received, and in recognition to what is important to patients, we put a special emphasis on long term outcomes as well as on educational aspects in the trial design. Publisher Copyright: © Author(s) (or their employer(s)) 2022.

PY - 2022/2/23

Y1 - 2022/2/23

KW - dermatology

KW - eczema

KW - occupational dermatology

KW - photodermatology

UR - https://www.scopus.com/pages/publications/85125156024

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DO - 10.1136/bmjopen-2021-060029

M3 - Article

C2 - 35197358

AN - SCOPUS:85125156024

SN - 2044-6055

VL - 12

JO - BMJ Open

JF - BMJ Open

IS - 2

M1 - e060029

ER -

Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial

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Keywords

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