Correlation between non-alcoholic fatty liver disease and metabolic parameters in persons with newly diagnosed type 2 diabetes mellitus

Supriyo Mukherjee (Corresponding / Lead Author), Sushmita Mukherjee, Chun Shing Kwok, Anne Phillips

    Research output: Contribution to journalArticlepeer-review

    Abstract

    BACKGROUND
    There are limited studies investigating the association between type 2 diabetes
    mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) in the region of
    Bihar, India.
    AIM
    To estimate the prevalence of NAFLD in persons with newly diagnosed T2DM in
    the population of North Bihar, India.
    METHODS
    This single centre cross-sectional study was undertaken in the Research Centre for
    Diabetes Hypertension and Obesity, Samastipur, Bihar, India. Data were collected
    from persons newly diagnosed with T2DM or those diagnosed within 6 months of
    when the study was conducted between December 2022 to May 2023.
    RESULTS
    A total of 148 people with newly diagnosed T2DM were included (median age 47
    years, 46.6% female) and 109 patients with liver disease on ultrasound evaluation.
    The persons with liver disease consumed more fats and oils (88.1% vs 74.4%, P =
    Mukherjee S et al. NAFLD in newly detected T2DM
    WJH https://www.wjgnet.com 1 August 27, 2024 Volume 16 Issue 8
    0.042) and they had significantly greater body mass index (27.4 vs 23.0, P < 0.001), waist circumference (37 vs 33, P <
    0.001), and waist-to-hip ratio (1.00 vs 0.70, P = 0.025). Females were associated with greater liver disease [odds ratio
    (OR): 3.09, 95% confidence interval (CI): 1.09-8.80, P = 0.32]. Waist circumference (OR: 1.42, 95%CI: 1.22-1.66, P <
    0.001) and low-density lipoprotein cholesterol (OR: 1.01, 95%CI: 1.01-1.02, P = 0.048) were associated with any liver
    disease. The factors most associated with grade 2/3 liver disease was right upper quadrant pain or heaviness (OR:
    5.22, 95%CI: 1.40-19.41, P = 0.14), greater income (OR: 3.58, 95%CI: 1.28-10.04, P = 0.015) and waist circumference
    (OR: 1.31, 95%CI: 1.02-1.69, P = 0.036).
    CONCLUSION
    NAFLD is common in new/recently diagnosed T2DM and disease burden is high and common among patients
    who are either high consumers of fats and oils or have obesity-associated markers.
    Original languageEnglish
    JournalWorld Journal of Hepatology
    Volume16
    Issue number8
    DOIs
    Publication statusPublished (VoR) - 27 Aug 2024

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