CSTI-300 (SMP-100); a novel 5-HT3 receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes

Alexander Roberts; Gillian Grafton; Andrew D. Powell; Kristian Brock; Chunlin Chen; Dejian Xie; Jinkun Huang; Shuang Liu; Alison J. Cooper; Catherine A. Brady; Omar Qureshi; Zania Stamataki; David D. Manning; Nicholas A. Moore; Bruce J. Sargent; Peter R. Guzzo; Nicholas M. Barnes

doi:10.1124/jpet.119.261008

CSTI-300 (SMP-100); a novel 5-HT₃ receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes

Alexander Roberts
, Gillian Grafton
, Andrew D. Powell
, Kristian Brock
, Chunlin Chen
, Dejian Xie
, Jinkun Huang
, Shuang Liu
, Alison J. Cooper
, Catherine A. Brady
, Omar Qureshi
, Zania Stamataki
, David D. Manning
, Nicholas A. Moore
, Bruce J. Sargent
, Peter R. Guzzo
, Nicholas M. Barnes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (SciVal)

Original language	English
Pages (from-to)	122-134
Number of pages	13
Journal	Journal of Pharmacology and Experimental Therapeutics
Volume	373
Issue number	1
DOIs	https://doi.org/10.1124/jpet.119.261008
Publication status	Published (VoR) - 1 Apr 2020

Funding

Funded as a research and development program by Albany Molecular Research, Inc., Chengdu SciMount Pharmatech Co. Ltd, and ConSynance Therapeutics, Inc.

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10.1124/jpet.119.261008

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Roberts, A., Grafton, G., Powell, A. D., Brock, K., Chen, C., Xie, D., Huang, J., Liu, S., Cooper, A. J., Brady, C. A., Qureshi, O., Stamataki, Z., Manning, D. D., Moore, N. A., Sargent, B. J., Guzzo, P. R., & Barnes, N. M. (2020). CSTI-300 (SMP-100); a novel 5-HT₃ receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes. Journal of Pharmacology and Experimental Therapeutics, 373(1), 122-134. https://doi.org/10.1124/jpet.119.261008

@article{e6ec9b06f94842e39db21fd3d56788fd,

title = "CSTI-300 (SMP-100); a novel 5-HT3 receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes",

author = "Alexander Roberts and Gillian Grafton and Powell, \{Andrew D.\} and Kristian Brock and Chunlin Chen and Dejian Xie and Jinkun Huang and Shuang Liu and Cooper, \{Alison J.\} and Brady, \{Catherine A.\} and Omar Qureshi and Zania Stamataki and Manning, \{David D.\} and Moore, \{Nicholas A.\} and Sargent, \{Bruce J.\} and Guzzo, \{Peter R.\} and Barnes, \{Nicholas M.\}",

note = "Funding Information: Funded as a research and development program by Albany Molecular Research, Inc., Chengdu SciMount Pharmatech Co. Ltd, and ConSynance Therapeutics, Inc. Publisher Copyright: Copyright {\textcopyright} 2020 by The American Society for Pharmacology and Experimental Therapeutics.",

year = "2020",

month = apr,

day = "1",

doi = "10.1124/jpet.119.261008",

language = "English",

volume = "373",

pages = "122--134",

journal = "Journal of Pharmacology and Experimental Therapeutics",

issn = "0022-3565",

publisher = "American Society for Pharmacology and Experimental Therapeutics",

number = "1",

}

Roberts, A, Grafton, G, Powell, AD, Brock, K, Chen, C, Xie, D, Huang, J, Liu, S, Cooper, AJ, Brady, CA, Qureshi, O, Stamataki, Z, Manning, DD, Moore, NA, Sargent, BJ, Guzzo, PR & Barnes, NM 2020, 'CSTI-300 (SMP-100); a novel 5-HT₃ receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes', Journal of Pharmacology and Experimental Therapeutics, vol. 373, no. 1, pp. 122-134. https://doi.org/10.1124/jpet.119.261008

CSTI-300 (SMP-100); a novel 5-HT₃ receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes. / Roberts, Alexander; Grafton, Gillian; Powell, Andrew D. et al.
In: Journal of Pharmacology and Experimental Therapeutics, Vol. 373, No. 1, 01.04.2020, p. 122-134.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - CSTI-300 (SMP-100); a novel 5-HT3 receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes

AU - Roberts, Alexander

AU - Grafton, Gillian

AU - Powell, Andrew D.

AU - Brock, Kristian

AU - Chen, Chunlin

AU - Xie, Dejian

AU - Huang, Jinkun

AU - Liu, Shuang

AU - Cooper, Alison J.

AU - Brady, Catherine A.

AU - Qureshi, Omar

AU - Stamataki, Zania

AU - Manning, David D.

AU - Moore, Nicholas A.

AU - Sargent, Bruce J.

AU - Guzzo, Peter R.

AU - Barnes, Nicholas M.

N1 - Funding Information: Funded as a research and development program by Albany Molecular Research, Inc., Chengdu SciMount Pharmatech Co. Ltd, and ConSynance Therapeutics, Inc. Publisher Copyright: Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.

PY - 2020/4/1

Y1 - 2020/4/1

UR - https://www.scopus.com/pages/publications/85082093389

UR - https://www.scopus.com/pages/publications/85082093389#tab=citedBy

U2 - 10.1124/jpet.119.261008

DO - 10.1124/jpet.119.261008

M3 - Article

C2 - 32102919

AN - SCOPUS:85082093389

SN - 0022-3565

VL - 373

SP - 122

EP - 134

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

IS - 1

ER -

CSTI-300 (SMP-100); a novel 5-HT₃ receptor partial agonist with potential to treat patients with irritable bowel syndrome or carcinoid syndromes

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