Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility

Joana Vieira Silva, Maria João Freitas, Joana Santiago, Sarah Jones, Sofia Guimarães, Srinivasan Vijayaraghavan, Steven Publicover, Giorgio Colombo, John Howl, Margarida Fardilha*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    9 Citations (SciVal)
    Original languageEnglish
    Pages (from-to)348-362
    Number of pages15
    JournalFertility and Sterility
    Volume115
    Issue number2
    DOIs
    Publication statusPublished (VoR) - Feb 2021

    Funding

    Supported by Fundo Europeu de Desenvolvimento Regional funds through the “ Programa Operacional Competitividade e Internacionalização COMPETE 2020 ,” national funds through the Fundação para a Ciência e Tecnologia ( PTDB/BBB-BQB/3804/2014 ), iBiMED ( UIDB/04501/2020 and POCI-01-0145-FEDER-007628 ), and an individual grant from Fundação para a Ciência e Tecnologia to J.V.S.( SFRH/BPD/123155/2016 ).

    FundersFunder number
    Fundação para a Ciência e a TecnologiaSFRH/BPD/123155/2016, POCI-01-0145-FEDER-007628, UIDB/04501/2020, PTDB/BBB-BQB/3804/2014
    European Regional Development Fund

      Keywords

      • male contraception
      • PP1-disrupting peptides
      • protein phosphatase 1
      • protein-protein interactions
      • Sperm motility

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