DNA methylation and body-mass index: A genome-wide analysis

Katherine J. Dick; Christopher P. Nelson; Loukia Tsaprouni; Johanna K. Sandling; Dylan Aïssi; Simone Wahl; Eshwar Meduri; Pierre Emmanuel Morange; France Gagnon; Harald Grallert; Melanie Waldenberger; Annette Peters; Jeanette Erdmann; Christian Hengstenberg; Francois Cambien; Alison H. Goodall; Willem H. Ouwehand; Heribert Schunkert; John R. Thompson; Tim D. Spector; Christian Gieger; David Alexandre Trégouët; Panos Deloukas; Nilesh J. Samani

doi:10.1016/S0140-6736(13)62674-4

DNA methylation and body-mass index: A genome-wide analysis

Katherine J. Dick, Christopher P. Nelson, Loukia Tsaprouni, Johanna K. Sandling, Dylan Aïssi, Simone Wahl, Eshwar Meduri, Pierre Emmanuel Morange, France Gagnon, Harald Grallert, Melanie Waldenberger, Annette Peters, Jeanette Erdmann, Christian Hengstenberg, Francois Cambien, Alison H. Goodall, Willem H. Ouwehand, Heribert Schunkert, John R. Thompson, Tim D. SpectorChristian Gieger, David Alexandre Trégouët, Panos Deloukas, Nilesh J. Samani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

641 Citations (SciVal)

Original language	English
Pages (from-to)	1990-1998
Number of pages	9
Journal	The Lancet
Volume	383
Issue number	9933
DOIs	https://doi.org/10.1016/S0140-6736(13)62674-4
Publication status	Published (VoR) - 2014

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10.1016/S0140-6736(13)62674-4

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Dick, K. J., Nelson, C. P., Tsaprouni, L., Sandling, J. K., Aïssi, D., Wahl, S., Meduri, E., Morange, P. E., Gagnon, F., Grallert, H., Waldenberger, M., Peters, A., Erdmann, J., Hengstenberg, C., Cambien, F., Goodall, A. H., Ouwehand, W. H., Schunkert, H., Thompson, J. R., ... Samani, N. J. (2014). DNA methylation and body-mass index: A genome-wide analysis. The Lancet, 383(9933), 1990-1998. https://doi.org/10.1016/S0140-6736(13)62674-4

@article{f8d9e590ba324f0080cc4a0924f5c0b0,

title = "DNA methylation and body-mass index: A genome-wide analysis",

author = "Dick, {Katherine J.} and Nelson, {Christopher P.} and Loukia Tsaprouni and Sandling, {Johanna K.} and Dylan A{\"i}ssi and Simone Wahl and Eshwar Meduri and Morange, {Pierre Emmanuel} and France Gagnon and Harald Grallert and Melanie Waldenberger and Annette Peters and Jeanette Erdmann and Christian Hengstenberg and Francois Cambien and Goodall, {Alison H.} and Ouwehand, {Willem H.} and Heribert Schunkert and Thompson, {John R.} and Spector, {Tim D.} and Christian Gieger and Tr{\'e}gou{\"e}t, {David Alexandre} and Panos Deloukas and Samani, {Nilesh J.}",

note = "Funding Information: This work was done as part of the Cardiogenics Project, which is funded by the European Union ( LSHM-CT 2006–037593 ). The MARTHA project was supported by a grant from the Program Hospitalier de Recherche Clinique, and the methylation array typing was funded by the Canadian Institutes of Health Research ( grant MOP 86466 ) and the Heart and Stroke Foundation of Canada ( grant T6484 ). Statistical analyses of the MARTHA datasets were done in the C2BIG computing centre (UPMC, Paris, France), which is funded by the Fondation pour la Recherche M{\'e}dicale and R{\'e}gion Ile de France. The KORA study was initiated and financed by the Helmholtz Zentrum M{\"u}nchen—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. The MuTHER study was funded by a programme grant from the Wellcome Trust ( 081917/Z/07/Z ), and receives support from the National Institute for Health Research BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. CPN is funded by the National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, and this work comes under the portfolio of translational research supported by this unit. DA was supported by a PhD grant from the R{\'e}gion Ile de France (CORDDIM). FG holds a Canada Research Chair. JE, FC, HS, D-AT, and NJS collaborate under a Fondation Leducq Grant ( 12CVD02 ). TDS is a European Research Council Senior Investigator and is holder of an ERC Advanced Principal Investigator award. PD is supported by the Wellcome Trust core grant to the Wellcome Trust Sanger Institute ( 098051 ), which funded DNA methylation analysis for MuTHER. NJS holds a chair funded by the British Heart Foundation and is a National Institute for Health Research Senior Investigator. We thank the staff from the genotyping facilities at the Wellcome Trust Sanger Institute for sample preparation, quality control, and typing for the Cardiogenics and MuTHER cohorts. Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

doi = "10.1016/S0140-6736(13)62674-4",

language = "English",

volume = "383",

pages = "1990--1998",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "9933",

}

Dick, KJ, Nelson, CP, Tsaprouni, L, Sandling, JK, Aïssi, D, Wahl, S, Meduri, E, Morange, PE, Gagnon, F, Grallert, H, Waldenberger, M, Peters, A, Erdmann, J, Hengstenberg, C, Cambien, F, Goodall, AH, Ouwehand, WH, Schunkert, H, Thompson, JR, Spector, TD, Gieger, C, Trégouët, DA, Deloukas, P & Samani, NJ 2014, 'DNA methylation and body-mass index: A genome-wide analysis', The Lancet, vol. 383, no. 9933, pp. 1990-1998. https://doi.org/10.1016/S0140-6736(13)62674-4

TY - JOUR

T1 - DNA methylation and body-mass index

T2 - A genome-wide analysis

AU - Dick, Katherine J.

AU - Nelson, Christopher P.

AU - Tsaprouni, Loukia

AU - Sandling, Johanna K.

AU - Aïssi, Dylan

AU - Wahl, Simone

AU - Meduri, Eshwar

AU - Morange, Pierre Emmanuel

AU - Gagnon, France

AU - Grallert, Harald

AU - Waldenberger, Melanie

AU - Peters, Annette

AU - Erdmann, Jeanette

AU - Hengstenberg, Christian

AU - Cambien, Francois

AU - Goodall, Alison H.

AU - Ouwehand, Willem H.

AU - Schunkert, Heribert

AU - Thompson, John R.

AU - Spector, Tim D.

AU - Gieger, Christian

AU - Trégouët, David Alexandre

AU - Deloukas, Panos

AU - Samani, Nilesh J.

N1 - Funding Information: This work was done as part of the Cardiogenics Project, which is funded by the European Union ( LSHM-CT 2006–037593 ). The MARTHA project was supported by a grant from the Program Hospitalier de Recherche Clinique, and the methylation array typing was funded by the Canadian Institutes of Health Research ( grant MOP 86466 ) and the Heart and Stroke Foundation of Canada ( grant T6484 ). Statistical analyses of the MARTHA datasets were done in the C2BIG computing centre (UPMC, Paris, France), which is funded by the Fondation pour la Recherche Médicale and Région Ile de France. The KORA study was initiated and financed by the Helmholtz Zentrum München—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. The MuTHER study was funded by a programme grant from the Wellcome Trust ( 081917/Z/07/Z ), and receives support from the National Institute for Health Research BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. CPN is funded by the National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, and this work comes under the portfolio of translational research supported by this unit. DA was supported by a PhD grant from the Région Ile de France (CORDDIM). FG holds a Canada Research Chair. JE, FC, HS, D-AT, and NJS collaborate under a Fondation Leducq Grant ( 12CVD02 ). TDS is a European Research Council Senior Investigator and is holder of an ERC Advanced Principal Investigator award. PD is supported by the Wellcome Trust core grant to the Wellcome Trust Sanger Institute ( 098051 ), which funded DNA methylation analysis for MuTHER. NJS holds a chair funded by the British Heart Foundation and is a National Institute for Health Research Senior Investigator. We thank the staff from the genotyping facilities at the Wellcome Trust Sanger Institute for sample preparation, quality control, and typing for the Cardiogenics and MuTHER cohorts. Publisher Copyright: © 2014 Elsevier Ltd.

PY - 2014

Y1 - 2014

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UR - http://www.scopus.com/inward/citedby.url?scp=84921316380&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(13)62674-4

DO - 10.1016/S0140-6736(13)62674-4

M3 - Article

C2 - 24630777

AN - SCOPUS:84921316380

SN - 0140-6736

VL - 383

SP - 1990

EP - 1998

JO - The Lancet

JF - The Lancet

IS - 9933

ER -

DNA methylation and body-mass index: A genome-wide analysis

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