Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial

for the UK WOLLF Collaboration

doi:10.1001/jama.2018.6452

Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial

for the UK WOLLF Collaboration

University of Oxford
The University of Warwick
University Hospitals Coventry and Warwickshire NHS Trust
Brighton and Sussex University Hospitals NHS Trust
University Hospitals Birmingham NHS Foundation Trust
University Hospitals of Derby and Burton NHS Foundation Trust
University Hospital Southampton NHS Foundation Trust
Sheffield Teaching Hospital NHS Foundation Trust
Poole Hospital NHS Trust
University of Leeds
South Tees Hospitals NHS Foundation Trust
Newcastle upon Tyne Hospitals NHS Foundation Trust
Cambridge University Hospitals NHS Foundation Trust
North Bristol NHS Trust
Portsmouth Hospitals NHS Trust
Norfolk and Norwich University Hospitals NHS Foundation Trust
University of Leicester
Royal Berkshire NHS Foundation Trust
Keele University
Liverpool University Hospitals NHS Foundation Trust
Oxford University Hospitals NHS Foundation Trust
University of Nottingham
University Health Board Wales
Barts Health NHS Trust
University Hospitals Plymouth NHS Trust
Hull University Teaching Hospitals NHS Trust
King’s College Hospital NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

148 Citations (SciVal)

Original language	English
Pages (from-to)	2280-2288
Number of pages	9
Journal	JAMA - Journal of the American Medical Association
Volume	319
Issue number	22
DOIs	https://doi.org/10.1001/jama.2018.6452
Publication status	Published (VoR) - 12 Jun 2018

Funding

completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Costa reported receiving a grant from the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) and is a member of its general board. Dr Achten reported receiving grants from the NIHR. Dr Lamb reported receiving grants from NIHR HTA and being a member of the NIHR HTA Additional Capacity Funding Board, HTA end of life care and add-on studies, HTA Prioritisation Group, and HTA Trauma Board. Dr Parsons reported receiving grants from the University of Warwick. No other disclosures were reported. Funding/Support: This project was funded by the UK NIHR HTA Programme (project No. 10/57/20) and was supported by the NIHR Oxford Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care in Oxford. The 2 main commercial entities (Smith & Nephew and KCI Medical) in this sector funded the excess treatment costs of the negative pressure wound therapy dressings but had no part in the design, conduct, or reporting of the trial.

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10.1001/jama.2018.6452

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@article{20a8faa273194db7ae5e6fcde406f66c,

title = "Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial",

author = "\{for the UK WOLLF Collaboration\} and Costa, \{Matthew L.\} and Juul Achten and Julie Bruce and Elizabeth Tutton and Stavros Petrou and Lamb, \{Sarah E.\} and Parsons, \{Nick R.\} and Benedict Rogers and Willett, \{Include Keith\} and Damian Griffin and Steven Jeffery and Jill Arrowsmith and Gorav Datta and Mick Dennison and Mark Farrar and Peter Giannoudis and Andrew Gray and Philip Henman and Peter Hull and Umraz Khan and Charlotte Lewis and David Loveday and Jitendra Mangwani and Andrew McAndrew and Damian McClelland and Mike McNicholas and David Noyes and Ben Ollivere and Ian Pallister and Keith Porter and Manoj Ramachandran and Rory Rickard and Hemant Sharma and Adel Tavakkolizadeh and Jonathan Young",

note = "Funding Information: completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Costa reported receiving a grant from the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) and is a member of its general board. Dr Achten reported receiving grants from the NIHR. Dr Lamb reported receiving grants from NIHR HTA and being a member of the NIHR HTA Additional Capacity Funding Board, HTA end of life care and add-on studies, HTA Prioritisation Group, and HTA Trauma Board. Dr Parsons reported receiving grants from the University of Warwick. No other disclosures were reported. Funding Information: Funding/Support: This project was funded by the UK NIHR HTA Programme (project No. 10/57/20) and was supported by the NIHR Oxford Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care in Oxford. The 2 main commercial entities (Smith \& Nephew and KCI Medical) in this sector funded the excess treatment costs of the negative pressure wound therapy dressings but had no part in the design, conduct, or reporting of the trial. Publisher Copyright: {\textcopyright} 2018 American Medical Association. All rights reserved.",

year = "2018",

month = jun,

day = "12",

doi = "10.1001/jama.2018.6452",

language = "English",

volume = "319",

pages = "2280--2288",

journal = "JAMA - Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "22",

}

Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial. / for the UK WOLLF Collaboration.
In: JAMA - Journal of the American Medical Association, Vol. 319, No. 22, 12.06.2018, p. 2280-2288.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial

AU - for the UK WOLLF Collaboration

AU - Costa, Matthew L.

AU - Achten, Juul

AU - Bruce, Julie

AU - Tutton, Elizabeth

AU - Petrou, Stavros

AU - Lamb, Sarah E.

AU - Parsons, Nick R.

AU - Rogers, Benedict

AU - Willett, Include Keith

AU - Griffin, Damian

AU - Jeffery, Steven

AU - Arrowsmith, Jill

AU - Datta, Gorav

AU - Dennison, Mick

AU - Farrar, Mark

AU - Giannoudis, Peter

AU - Gray, Andrew

AU - Henman, Philip

AU - Hull, Peter

AU - Khan, Umraz

AU - Lewis, Charlotte

AU - Loveday, David

AU - Mangwani, Jitendra

AU - McAndrew, Andrew

AU - McClelland, Damian

AU - McNicholas, Mike

AU - Noyes, David

AU - Ollivere, Ben

AU - Pallister, Ian

AU - Porter, Keith

AU - Ramachandran, Manoj

AU - Rickard, Rory

AU - Sharma, Hemant

AU - Tavakkolizadeh, Adel

AU - Young, Jonathan

N1 - Funding Information: completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Costa reported receiving a grant from the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) and is a member of its general board. Dr Achten reported receiving grants from the NIHR. Dr Lamb reported receiving grants from NIHR HTA and being a member of the NIHR HTA Additional Capacity Funding Board, HTA end of life care and add-on studies, HTA Prioritisation Group, and HTA Trauma Board. Dr Parsons reported receiving grants from the University of Warwick. No other disclosures were reported. Funding Information: Funding/Support: This project was funded by the UK NIHR HTA Programme (project No. 10/57/20) and was supported by the NIHR Oxford Biomedical Research Centre and the NIHR Collaboration for Leadership in Applied Health Research and Care in Oxford. The 2 main commercial entities (Smith & Nephew and KCI Medical) in this sector funded the excess treatment costs of the negative pressure wound therapy dressings but had no part in the design, conduct, or reporting of the trial. Publisher Copyright: © 2018 American Medical Association. All rights reserved.

PY - 2018/6/12

Y1 - 2018/6/12

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UR - https://www.scopus.com/pages/publications/85048566430#tab=citedBy

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AN - SCOPUS:85048566430

SN - 0098-7484

VL - 319

SP - 2280

EP - 2288

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 22

ER -

Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb the wollf randomized clinical trial

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