Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial

Somaye Yosaee; Sepideh Soltani; Alireza Esteghamati; Seyed Abbas Motevalian; Mehdi Tehrani-Doost; Cain C.T. Clark; Shima Jazayeri

doi:10.1016/j.nut.2019.110601

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial

Somaye Yosaee, Sepideh Soltani, Alireza Esteghamati, Seyed Abbas Motevalian, Mehdi Tehrani-Doost, Cain C.T. Clark, Shima Jazayeri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (SciVal)

Original language	English
Article number	110601
Journal	Nutrition
Volume	71
DOIs	https://doi.org/10.1016/j.nut.2019.110601
Publication status	Published (VoR) - Mar 2020

Funding

This study was performed according to the principles of the Declaration of Helsinki, and the study protocol was approved by the institutional ethics committee of Iran University of Medical Sciences (IR.IUMS.REC 1395.9221324205). The study protocol was carefully explained to all participants signing an informed consent form. This trial was registered on the Iranian website ( www.irct.ir ) for registration of clinical trials ( http://www.irct.ir: IRCT201601252394 N31- 31-10-2016). The project was financially supported by Iran University of Medical Sciences.

Funders	Funder number
Iran University of Medical Sciences

Keywords

BDNF
Cortisol
Depression
Obesity

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Yosaee, S., Soltani, S., Esteghamati, A., Motevalian, S. A., Tehrani-Doost, M., Clark, C. C. T., & Jazayeri, S. (2020). Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition, 71, Article 110601. https://doi.org/10.1016/j.nut.2019.110601

Yosaee, Somaye ; Soltani, Sepideh ; Esteghamati, Alireza et al. / Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms : A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. In: Nutrition. 2020 ; Vol. 71.

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title = "Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial",

keywords = "BDNF, Cortisol, Depression, Obesity",

author = "Somaye Yosaee and Sepideh Soltani and Alireza Esteghamati and Motevalian, {Seyed Abbas} and Mehdi Tehrani-Doost and Clark, {Cain C.T.} and Shima Jazayeri",

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Yosaee, S, Soltani, S, Esteghamati, A, Motevalian, SA, Tehrani-Doost, M, Clark, CCT & Jazayeri, S 2020, 'Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial', Nutrition, vol. 71, 110601. https://doi.org/10.1016/j.nut.2019.110601

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. / Yosaee, Somaye; Soltani, Sepideh; Esteghamati, Alireza et al.
In: Nutrition, Vol. 71, 110601, 03.2020.

Research output: Contribution to journal › Article › peer-review

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AU - Clark, Cain C.T.

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Yosaee S, Soltani S, Esteghamati A, Motevalian SA, Tehrani-Doost M, Clark CCT et al. Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition. 2020 Mar;71:110601. doi: 10.1016/j.nut.2019.110601

Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial

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Keywords

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Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial