TY - JOUR
T1 - Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years
AU - Jemni, Monèm
AU - Zaman, Rashid
AU - Carrick, Frederick Robert
AU - Clarke, Neil David
AU - Marina, Michel
AU - Bottoms, Lindsay
AU - Matharoo, Jagdeep Singh
AU - Ramsbottom, Roger
AU - Hoffman, Norman
AU - Groves, Shad James
AU - Gu, Yaodong
AU - Konukman, Ferman
N1 - Publisher Copyright:
Copyright © 2023 Jemni, Zaman, Carrick, Clarke, Marina, Bottoms, Matharoo, Ramsbottom, Hoffman, Groves, Gu and Konukman.
PY - 2023/3/8
Y1 - 2023/3/8
N2 - The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.
AB - The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.
KW - BDNF expression
KW - depression treatment
KW - exercise mode
KW - neuroplasticity
KW - physical activity intervention
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U2 - 10.3389/fphys.2023.1102526
DO - 10.3389/fphys.2023.1102526
M3 - Review article
SN - 1664-042X
VL - 14
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 1102526
ER -