Original language | English |
---|---|
Pages (from-to) | 18-29 |
Number of pages | 12 |
Journal | Nature Genetics |
Volume | 54 |
Issue number | 1 |
DOIs | |
Publication status | Published (VoR) - Jan 2022 |
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Nature Genetics, Vol. 54, No. 1, 01.2022, p. 18-29.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
AU - MuTHER Consortium
AU - Hawe, Johann S.
AU - Wilson, Rory
AU - Schmid, Katharina T.
AU - Zhou, Li
AU - Lakshmanan, Lakshmi Narayanan
AU - Lehne, Benjamin C.
AU - Kühnel, Brigitte
AU - Scott, William R.
AU - Wielscher, Matthias
AU - Yew, Yik Weng
AU - Baumbach, Clemens
AU - Lee, Dominic P.
AU - Marouli, Eirini
AU - Bernard, Manon
AU - Pfeiffer, Liliane
AU - Matías-García, Pamela R.
AU - Autio, Matias I.
AU - Bourgeois, Stephane
AU - Herder, Christian
AU - Karhunen, Ville
AU - Meitinger, Thomas
AU - Prokisch, Holger
AU - Rathmann, Wolfgang
AU - Roden, Michael
AU - Sebert, Sylvain
AU - Shin, Jean
AU - Strauch, Konstantin
AU - Zhang, Weihua
AU - Tan, Wilson L.W.
AU - Hauck, Stefanie M.
AU - Merl-Pham, Juliane
AU - Grallert, Harald
AU - Barbosa, Eudes G.V.
AU - Ahmadi, Kourosh R.
AU - Ainali, Chrysanthi
AU - Barrett, Amy
AU - Bataille, Veronique
AU - Bell, Jordana T.
AU - Buil, Alfonso
AU - Dermitzakis, Emmanouil T.
AU - Dimas, Antigone S.
AU - Durbin, Richard
AU - Glass, Daniel
AU - Grundberg, Elin
AU - Hassanali, Neelam
AU - Hedman, Åsa K.
AU - Ingle, Catherine
AU - Knowles, David
AU - Krestyaninova, Maria
AU - Tsaprouni, Loukia
N1 - Funding Information: The KORA study was initiated and financed by the Helmholtz Zentrum München (German Research Center for Environmental Health), which is funded by the German Federal Ministry of Education and Research (BMBF) and by the state of Bavaria. KORA research was supported within the Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universität, as part of LMUinnovativ. The work was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the EU Joint Programming Initiative ‘a Healthy Diet for a Healthy Life’ (DIMENSION grant number 01EA1902A). The work was further supported by the Bavarian State Ministry of Health and Care through the research project DigiMed Bayern (https:// www.digimed-bayern.de/). The German Diabetes Center (DDZ) is supported by the Ministry of Culture and Science of the State of North Rhine–Westphalia and the German Federal Ministry of Health. This study was supported in part by a grant from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (DZD). The LOLIPOP study is supported by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, the British Heart Foundation (SP/04/002), the Medical Research Council (G0601966, G0700931), the Wellcome Trust (084723/Z/08/Z), the NIHR (RP-PG-0407-10371), European Union FP7 (EpiMigrant, 279143) and European Union Horizon 2020 (iHealth-T2D, 643774). B.C.L. is supported by the Imperial College Junior Research Fellowship scheme as well as an Academy of Medical Sciences Springboard award. J.C.C. is also supported by the Singapore NMRC (NMRC/ STaR/0028/2017). We thank the participants and research staff who made the study possible. For the Northern Finnish Birth Cohort studies, M. Wielscher was supported by the European Union’s Horizon 2020 research and innovation program (grant 633212). NFBC1966 received financial support from the Academy of Finland (grants 104781, 120315, 129269, 1114194 and 24300796, Center of Excellence in Complex Disease Genetics and SALVE), University Hospital Oulu, Biocenter, University of Oulu, Finland (75617), NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), the NIH–NIMH (5R01MH63706:02), the ENGAGE project and grant agreement HEALTH-F4-2007-201413, EU FP7 EurHEALTHAgeing (277849), the Medical Research Council, UK (G0500539, G0600705, G1002319, PrevMetSyn/SALVE) and an MRC Centenary Early Career Award. NFBC1986 received financial support from EU QLG1-CT-2000-01643 (EUROBLCS) grant E51560, NorFA grant nos. 731, 20056 and 30167 and USA/NIHH 2000 G DF682 grant 50945. The NFBC programs are also funded by the H2020-633595 DynaHEALTH action, the Academy of Finland Exposomic, Genomic and Epigenomic Approach to Prediction of Metabolic and Cardiorespiratory Function and Ill-Health project (285547) and the EU H2020 ALEC project (grant agreement 633212). The MuTHER study was funded by the WT (081917/Z/07/Z). TwinsUK was funded by the WT and the European Community’s Seventh Framework Programme (FP7/2007-2013). The study also received support from the NIHR Clinical Research Facility at Guy’s and St. Thomas’ and King’s College London. Analysis was funded by British Heart Foundation grant RG/14/5/30893 to P.D. and forms part of the research themes contributing to the translational research portfolio of the Barts Cardiovascular Biomedical Research Unit, which is funded by the NIHR. The Saguenay Youth Study has been funded by the Canadian Institutes of Health Research (T.P., Z.P.), the Heart and Stroke Foundation of Canada (Z.P.) and the Canadian Foundation for Innovation (Z.P.). We acknowledge G. Möller and J. Adamski (Helmholtz Center Munich) for their support in the IP–MS transfection experiment. We used data generated by the PCHI-C Consortium31, funded by the UK NIHR, the Medical Research Council (MR/ L007150/1) and the Biotechnology and Biological Research Council (BB/J004480/1). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/1
Y1 - 2022/1
UR - http://www.scopus.com/inward/record.url?scp=85122284960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122284960&partnerID=8YFLogxK
U2 - 10.1038/s41588-021-00969-x
DO - 10.1038/s41588-021-00969-x
M3 - Article
AN - SCOPUS:85122284960
SN - 1061-4036
VL - 54
SP - 18
EP - 29
JO - Nature Genetics
JF - Nature Genetics
IS - 1
ER -