Genomewide association study of acute anterior uveitis identifies new susceptibility loci

Xiu Feng Huang, Zhixiu Li, Erika de Guzman, Philip Robinson, Lianne Gensler, Michael M. Ward, Mohammad Hossein Rahbar, Min Jae Lee, Michael H. Weisman, Gary J. Macfarlane, Gareth T. Jones, Eva Klingberg, Helena Forsblad-D’Elia, Peter McCluskey, Denis Wakefield, Jeff S. Coombes, Maria A. Fiatarone Singh, Yorgi Mavros, Nicole Vlahovich, David C. HughesHelena Marzo-Ortega, Irene van der Horste-Bruinsma, Finbar O’Shea, Tammy M. Martin, James Rosenbaum, Maxime Breban, Zi Bing Jin, Paul Leo, John D. Reveille, B. Paul Wordsworth, Matthew A. Brown*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    35 Citations (SciVal)
    Original languageEnglish
    Article number3
    JournalInvestigative Ophthalmology and Visual Science
    Volume61
    Issue number6
    DOIs
    Publication statusPublished (VoR) - Jun 2020

    Funding

    The survey was conducted by NatCen and the genomewide scan data were analyzed and deposited by the Wellcome Trust Sanger Institute. Information on how to access the data can be found on the Understanding Society website https: www. understandingsociety.ac.uk/ . We acknowledge and thank the TCRA AS Group for their support in recruiting patients for the study. M.A.B. is funded by a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship, and support for this study was received from a National Health and Medical Research Council (Australia) program Grant (566938) and project Grant (569829), and from the Australian Cancer Research Foundation and Rebecca Cooper Medical Research Foundation. We are also very grateful for the invaluable support received from the National Ankylosing Spondylitis Society (UK) and Spondyloarthritis Association of America in case recruitment. Additional financial and technical support for patient recruitment was provided by the National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit and NIHR Thames Valley Comprehensive Local Research and an unrestricted educational grant from Abbott Laboratories. The authors acknowledge the sharing of data and samples by the BSRBR-AS Register in Aberdeen. Chief Investigator, Prof Gary Macfarlane and Dr Gareth Jones, Deputy Chief Investigator, created the BSRBR-AS study, which was commissioned by the British Society for Rheumatology, funded in part by Abbvie, Pfizer, and UCB. We are grateful to every patient, past and present staff of the BSRBR-AS register team, and to all clinical staff who recruited patients, followed them up and entered data – details here: https://www.abdn.ac.uk/iahs/research/ epidemiology/spondyloarthritis.php#panel1011. Funding was also received from the Swedish Research Council and The Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement. The Irish data was derived from participants in ASRI – The Ankylosing Spondylitis Registry of Ireland, which is funded by unrestricted grants from Abbvie and Pfizer. Funding bodies involved played no role in the study design, performance, or preparation of this manuscript. X.F.H. was funded by the National Natural Science Foundation of China (31771390). The TASC study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grants P01-052915, R01-AR046208. Funding was also received from the University of Texas Health Science Center at Houston CTSA grant UL1RR02418, Cedars-Sinai GCRC grant MO1-RR00425, Intramural Research Program, NIAMS/NIH, and Rebecca Cooper Foundation (Australia). This study was funded, in part, by Arthritis Research UK (Grants 19536 and 18797), by the Wellcome Trust (Grant number 076113), and by the Oxford Comprehensive Biomedical Research Centre ankylosing spondylitis chronic disease cohort (Theme Code: A91202). The New Zealand data was derived from participants in the Spondyloarthritis Genetics and the Environment Study (SAGE) and was funded by The Health Research Council, New Zealand. H.X. was funded by the National Natural Science Foundation of China Grant 81020108029 and 30872339. French sample collection was performed by the Groupe Française d’Etude Génétique des Spondylarthrites, coordinated by Professor Maxime Breban, and funded by the Agence Nationale de Recherche GEMISA grant reference ANR-10-MIDI-0002. We acknowledge the Understanding Society: The UK Household Longitudinal Study. This is led by the Institute for Social and Economic Research at the University of Essex and funded by the Economic and Social Research Council.

    FundersFunder number
    Cedars-Sinai GCRCMO1-RR00425
    Groupe Française d’Etude Génétique des Spondylarthrites
    Health Research Council, New Zealand30872339, 81020108029
    NIAMS/NIH
    National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit
    Spondyloarthritis Genetics and the Environment Study
    Swedish government
    University of Texas Health Science CenterUL1RR02418
    National Institute of Arthritis and Musculoskeletal and Skin DiseasesR01AR046208, P01-052915
    National Center for Research ResourcesM01RR000425
    Abbott Laboratories
    AbbVie
    Pfizer UK
    Wellcome Trust076113
    UCB Celltech
    Economic and Social Research Council
    Arthritis Research UK18797, 19536
    British Society for Rheumatology
    National Health and Medical Research Council569829, 566938
    Australian Cancer Research Foundation
    Rebecca L. Cooper Medical Research Foundation
    Agence Nationale de la RechercheANR-10-MIDI-0002
    National Natural Science Foundation of China31771390
    Vetenskapsrådet
    NIHR Clinical Research Network Thames Valley and South Midlands
    Asher Space Research Institute, Technion-Israel Institute of Technology
    NIHR Oxford Biomedical Research CentreA91202

      Keywords

      • Acute anterior uveitis
      • Ankylosing spondylitis
      • GWAS
      • Genetic risk scores
      • Heritability

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