@article{b0fc499c82ab462e8719598be9ccdf46,
title = "Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019",
author = "\{GBD 2019 Demographics Collaborators\} and C. Abbafati and Machado, \{D. B.\} and B. Cislaghi and Salman, \{O. M.\} and M. Karanikolos and M. McKee and Abbas, \{K. M.\} and Brady, \{O. J.\} and Larson, \{H. J.\} and S. Trias-Llim{\'o}s and S. Cummins and Langan, \{S. M.\} and B. Sartorius and A. Hafiz and E. Jenabi and \{Mohammad Gholi Mezerji\}, N. and S. Borzouei and G. Azarian and S. Khazaei and M. Abbasi and B. Asghari and S. Masoumi and H. Komaki and A. Taherkhani and M. Adabi and M. Abbasifard and G. Bazmandegan and Z. Kamiab and A. Vakilian and M. Anjomshoa and A. Mokari and S. Sabour and M. Shahbaz and R. Saeedi and H. Ahmadieh and T. Yousefinezhadi and A. Haj-Mirzaian and R. Nikbakhsh and S. Safi and S. Asgari and Irvani, \{S. N.\} and N. Jahanmehr and K. Ramezanzadeh and M. Abbasi-Kangevari and M. Khayamzadeh and H. Abbastabar and R. Shirkoohi and M. Fazlzadeh and H. Janjani and O. Aremu",
note = "Funding Information: Research reported in this publication was supported by the Bill \& Melinda Gates Foundation, the University of Melbourne, Public Health England, the Norwegian Institute of Public Health, the National Institute on Aging of the National Institutes of Health (NIH; award P30AG047845), and the National Institute of Mental Health of the NIH (award R01MH110163). This analysis uses data or information from the Longitudinal Aging Study in India (LASI) pilot micro data and documentation. The development and release of the LASI pilot study was funded by the National Institute on Aging of the NIH (R21AG032572, R03AG043052, and R01AG030153). The Palestinian Central Bureau of Statistics granted the researchers access to relevant data in accordance with license number SLN2014-3-170, after subjecting data to processing aiming to preserve the confidentiality of individual data in accordance with the General Statistics Law, 2000. The researchers are solely responsible for the conclusions and inferences drawn upon available data. Data were included from the Russia Longitudinal Monitoring survey, conducted by the National Research University Higher School of Economics and ZAO Demoscope together with Carolina Population Center, University of North Carolina at Chapel Hill and the Institute of Sociology, Russia Academy of Sciences. The United States Aging, Demographics, and Memory Study is a supplement to the Health and Retirement Study, which is sponsored by the National Institute of Aging (grant number NIA U01AG009740). It was conducted jointly by Duke University and the University of Michigan. L G Abreu acknowledges support from Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Brazil; finance code 001) and Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq, a Brazilian funding agency). O Adetokunboh acknowledges the South African Department of Science and Innovation and the National Research Foundation. A Agrawal acknowledges the Wellcome Trust DBT India Alliance Senior Fellowship. S Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. M Ausloos, C Herteliu, and A Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. T B?rnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. D Bennett acknowledges support by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the UK Department of Health and Social Care. J J Carrero was supported by the Swedish Research Council (2019-01059). F Caravlho and E Fernandes acknowledge support from UID/MULTI/04378/2019 and UID/QUI/50006/2019 with funding from FCT/MCTES through national funds. V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Funda??o para a Ci?ncia e Tecnologia, IP, under the Norma Transit?ria DL57/2016/CP1334/CT0006. K Deribe acknowledges support by the Wellcome Trust (201900/Z/16/Z) as part of his International Intermediate Fellowship. M Ferreira acknowledges her research fellowship from the National Health and Medical Research Council (NHMRC) of Australia. C Flohr acknowledges support by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust. M Freitas acknowledges financial support from the EU (European Regional Development Fund [FEDER] funds through COMPETE POCI-01-0145-FEDER-029248) and National Funds (Funda??o para a Ci?ncia e Tecnologia) through project PTDC/NAN-MAT/29248/2017. C Herteliu was partially supported by a grant co-funded by FEDER through Operational Competitiveness Program (project ID P\_40\_382). P Hoogar acknowledges the Bio Cultural Studies, Manipal Academy of Higher Education, and Manipal and Centre for Holistic Development and Research, Kalaghatgi. S V Katikireddi acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC\_UU\_12017/13, MC\_UU\_12017/15), and the Scottish Government Chief Scientist Office (SPHSU13, SPHSU15). Y J Kim was supported by Research Management Office, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). K Krishan is supported by the UCG Centre of Advanced Study awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar acknowledges the Fogarty International Centre and NIH for the K43 award (K43 TW 010716-03). B Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. J V Lazarus was supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III [ISCIII]/ESF, the EU [CP18/00074]). J McGrath acknowledges support by the Danish National Research Foundation (Niels Bohr Professorship). W Mendoza acknowledges the Population and Development department at the UN Population Fund Country Office in Peru, which does not necessarily endorse this study. George Milne acknowledges support provided by The University of Western Australia. I Moreno Vel?squez acknowledges support by the Sistema Nacional de Investigaci?n (SENACYT, Panam?). U O Mueller acknowledges funding by the German National Cohort Study (BMBF grant number 01ER1801D). S Nomura acknowledges the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). A Ortiz was supported by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. G C Patton was supported by a NHMRC fellowship. A Raggi, D Sattin, and S Schiavolin were supported by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4?Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). A M Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. D F Santomauro is affiliated with the Queensland Centre for Mental Health Research, which receives core funding from the Queensland Department of Health. M M Santric-Milicevic acknowledges the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract number 175087). A Sheikh was supported by Health Data Research UK. J B Soriano is funded by the Centro de Investigaci?n en Red de Enfermedades Respiratorias, ISCIII. R Tabar?s-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII?FEDER. S Tadakamadla was supported by an NHMRC Early Career Fellowship. N Taveira was partially supported by the European \& Developing Countries Clinical Trials Partnership, the EU (LIFE project, reference RIA2016MC-1615). M Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary. C S Wiysonge was supported by the South African Medical Research Council. S B Zaman received a scholarship from the Australian Government research training programme in support of his academic career. Editorial note: the Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations. Funding Information: Research reported in this publication was supported by the Bill \& Melinda Gates Foundation, the University of Melbourne, Public Health England, the Norwegian Institute of Public Health, the National Institute on Aging of the National Institutes of Health (NIH; award P30AG047845), and the National Institute of Mental Health of the NIH (award R01MH110163). This analysis uses data or information from the Longitudinal Aging Study in India (LASI) pilot micro data and documentation. The development and release of the LASI pilot study was funded by the National Institute on Aging of the NIH (R21AG032572, R03AG043052, and R01AG030153). The Palestinian Central Bureau of Statistics granted the researchers access to relevant data in accordance with license number SLN2014-3-170, after subjecting data to processing aiming to preserve the confidentiality of individual data in accordance with the General Statistics Law, 2000. The researchers are solely responsible for the conclusions and inferences drawn upon available data. Data were included from the Russia Longitudinal Monitoring survey, conducted by the National Research University Higher School of Economics and ZAO Demoscope together with Carolina Population Center, University of North Carolina at Chapel Hill and the Institute of Sociology, Russia Academy of Sciences. The United States Aging, Demographics, and Memory Study is a supplement to the Health and Retirement Study, which is sponsored by the National Institute of Aging (grant number NIA U01AG009740). It was conducted jointly by Duke University and the University of Michigan. L G Abreu acknowledges support from Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (Brazil; finance code 001) and Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq, a Brazilian funding agency). O Adetokunboh acknowledges the South African Department of Science and Innovation and the National Research Foundation. A Agrawal acknowledges the Wellcome Trust DBT India Alliance Senior Fellowship. S Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. M Ausloos, C Herteliu, and A Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. T B{\"a}rnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. D Bennett acknowledges support by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the UK Department of Health and Social Care. J J Carrero was supported by the Swedish Research Council (2019-01059). F Caravlho and E Fernandes acknowledge support from UID/MULTI/04378/2019 and UID/QUI/50006/2019 with funding from FCT/MCTES through national funds. V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia, IP, under the Norma Transit{\'o}ria DL57/2016/CP1334/CT0006. K Deribe acknowledges support by the Wellcome Trust (201900/Z/16/Z) as part of his International Intermediate Fellowship. M Ferreira acknowledges her research fellowship from the National Health and Medical Research Council (NHMRC) of Australia. C Flohr acknowledges support by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust. M Freitas acknowledges financial support from the EU (European Regional Development Fund [FEDER] funds through COMPETE POCI-01-0145-FEDER-029248) and National Funds (Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia) through project PTDC/NAN-MAT/29248/2017. C Herteliu was partially supported by a grant co-funded by FEDER through Operational Competitiveness Program (project ID P\_40\_382). P Hoogar acknowledges the Bio Cultural Studies, Manipal Academy of Higher Education, and Manipal and Centre for Holistic Development and Research, Kalaghatgi. S V Katikireddi acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC\_UU\_12017/13, MC\_UU\_12017/15), and the Scottish Government Chief Scientist Office (SPHSU13, SPHSU15). Y J Kim was supported by Research Management Office, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). K Krishan is supported by the UCG Centre of Advanced Study awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar acknowledges the Fogarty International Centre and NIH for the K43 award (K43 TW 010716-03). B Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. J V Lazarus was supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III [ISCIII]/ESF, the EU [CP18/00074]). J McGrath acknowledges support by the Danish National Research Foundation (Niels Bohr Professorship). W Mendoza acknowledges the Population and Development department at the UN Population Fund Country Office in Peru, which does not necessarily endorse this study. George Milne acknowledges support provided by The University of Western Australia. I Moreno Vel{\'a}squez acknowledges support by the Sistema Nacional de Investigaci{\'o}n (SENACYT, Panam{\'a}). U O Mueller acknowledges funding by the German National Cohort Study (BMBF grant number 01ER1801D). S Nomura acknowledges the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). A Ortiz was supported by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. G C Patton was supported by a NHMRC fellowship. A Raggi, D Sattin, and S Schiavolin were supported by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4—Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). A M Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. D F Santomauro is affiliated with the Queensland Centre for Mental Health Research, which receives core funding from the Queensland Department of Health. M M Santric-Milicevic acknowledges the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract number 175087). A Sheikh was supported by Health Data Research UK. J B Soriano is funded by the Centro de Investigaci{\'o}n en Red de Enfermedades Respiratorias, ISCIII. R Tabar{\'e}s-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII–FEDER. S Tadakamadla was supported by an NHMRC Early Career Fellowship. N Taveira was partially supported by the European \& Developing Countries Clinical Trials Partnership, the EU (LIFE project, reference RIA2016MC-1615). M Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary. C S Wiysonge was supported by the South African Medical Research Council. S B Zaman received a scholarship from the Australian Government research training programme in support of his academic career. Funding Information: R Ancuceanu reports consultancy and speakers' fees from UCB Pharmaceuticals, Sandoz, Abbvie, Zentiva, Teva, Laropharm, and Cegedim, outside of the submitted work. M Bell reports grants from the US Environmental Protection Agency, National Institutes of Health (NIH), and Wellcome, during the conduct of the study; and Honorarium or travel reimbursement from the NIH (for review of grant proposals), American Journal of Public Health (participation as editor), Global Research Laboratory and Seoul National University, Royal Society, Ohio University, Atmospheric Chemistry Gordon Research Conference, Johns Hopkins Bloomberg School of Public Health, Arizona State University, Ministry of the Environment Japan, Hong Kong Polytechnic University, University of Illinois—Champaign, and the University of Tennessee—Knoxville, outside of the submitted work. S James reports grants from Sanofi Pasteur, and employment from Genentech, outside of the submitted work. V Jha reports grants from Baxter Healthcare, GlaxoSmithKline, Zydus Cadilla, and Biocon, and personal fees from NephroPlus, outside of the submitted work. J J Jozwiak reports personal fees from Amgen, ALAB Laboratoria, Teva, Synexus, and Boehringer Ingelheim, outside of the submitted work. S Katikireddi reports grants from NRS Senior Clinical Fellowship, UK Medical Research Council, and Scottish Government Chief Scientist Office, during the conduct of the study. J Mosser reports grants from Bill \& Melinda Gates Foundation, during the conduct of the study. S Nomura reports grants from the Ministry of Education, Culture, Sports, Science, and Technology, both during the conduct of the study and outside of the submitted work. T Pilgrim reports grants and personal fees from Biotronik and from Boston Scientific, and grants from Edwards Lifesciences, outside of the submitted work. M Postma reports grants from BioMerieux, WHO, EU, FIND, Antilope, DIKTI, LPDP, Bayer, and Budi; personal fees from Quintiles, Novartis, and Pharmerit; grants and personal fees from IQVIA, Bristol Myers Squibb, AstraZeneca, Seqirus, Sanofi, Merck Sharp \& Dohme, GlaxoSmithKline, Pfizer, Boehringer Ingelheim, and Novavax; stocks from Ingress Health, and PAG; and acting as advisor to Asc Academics, all outside of the submitted work. M {\c S}aylan reports employment with Bayer, during the conduct of the study. M Shrime reports grants from Mercy Ships, and Damon Runyon Cancer Research Foundation, outside of the submitted work. J Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, NIH, and the American College of Rheumatology; personal fees from Simply Speaking; stock options in Amarin Pharmaceuticals and Viking Pharmaceuticals; membership in the steering committee of OMERACT (an international organisation that develops measures for clinical trials and receives arm's length funding from 12 pharmaceutical companies), US Food and Drug Administration Arthritis Advisory Committee, and the Veterans Affairs Rheumatology Field Advisory Committee; and non-financial support from UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, outside of the submitted work. A Thrift reports grants from National Health and Medical Research Council Australia, outside of the submitted work. F Topouzis reports grants from Pfizer, Thea, Novartis, Rheon, Omikron, Pharmaten, Bayer, and Bausch \& Lomb, and personal fees from Novartis, and Omikron, outside of the submitted work. M Wallin reports serving as a consultant on grants from Rand Corporation, outside of the submitted work. All other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",
year = "2020",
month = oct,
day = "17",
doi = "10.1016/S0140-6736(20)30977-6",
language = "English",
volume = "396",
pages = "1160--1203",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier",
number = "10258",
}