Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

Timokratis Karamitros; Tara Hurst; Emanuele Marchi; Eirini Karamichali; Urania Georgopoulou; Andreas Mentis; Joey Riepsaame; Audrey Lin; Dimitrios Paraskevis; Angelos Hatzakis; John McLauchlan; Aris Katzourakis; Gkikas Magiorkinis

doi:10.1073/pnas.1811940115

Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

Timokratis Karamitros, Tara Hurst, Emanuele Marchi, Eirini Karamichali, Urania Georgopoulou, Andreas Mentis, Joey Riepsaame, Audrey Lin, Dimitrios Paraskevis, Angelos Hatzakis, John McLauchlan, Aris Katzourakis^*, Gkikas Magiorkinis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (SciVal)

Original language	English
Pages (from-to)	10343-10439
Number of pages	97
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	115
Issue number	41
DOIs	https://doi.org/10.1073/pnas.1811940115
Publication status	Published (VoR) - 9 Oct 2018

Funding

ACKNOWLEDGMENTS. We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC_UU_12014/1). A.K. was funded by the Royal Society. We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC_UU_12014/1). A.K. was funded by the Royal Society.

Keywords

Addiction
Endogenous retrovirus
HERV-K HML-2
Persons who inject drugs
RASGRF2

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10.1073/pnas.1811940115

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Karamitros, T., Hurst, T., Marchi, E., Karamichali, E., Georgopoulou, U., Mentis, A., Riepsaame, J., Lin, A., Paraskevis, D., Hatzakis, A., McLauchlan, J., Katzourakis, A., & Magiorkinis, G. (2018). Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model. Proceedings of the National Academy of Sciences of the United States of America, 115(41), 10343-10439. https://doi.org/10.1073/pnas.1811940115

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title = "Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model",

keywords = "Addiction, Endogenous retrovirus, HERV-K HML-2, Persons who inject drugs, RASGRF2",

author = "Timokratis Karamitros and Tara Hurst and Emanuele Marchi and Eirini Karamichali and Urania Georgopoulou and Andreas Mentis and Joey Riepsaame and Audrey Lin and Dimitrios Paraskevis and Angelos Hatzakis and John McLauchlan and Aris Katzourakis and Gkikas Magiorkinis",

note = "Funding Information: ACKNOWLEDGMENTS. We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC\_UU\_12014/1). A.K. was funded by the Royal Society. Funding Information: We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC\_UU\_12014/1). A.K. was funded by the Royal Society. Publisher Copyright: {\textcopyright} 2018 National Academy of Sciences. All Rights Reserved.",

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doi = "10.1073/pnas.1811940115",

language = "English",

volume = "115",

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Karamitros, T, Hurst, T, Marchi, E, Karamichali, E, Georgopoulou, U, Mentis, A, Riepsaame, J, Lin, A, Paraskevis, D, Hatzakis, A, McLauchlan, J, Katzourakis, A & Magiorkinis, G 2018, 'Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 41, pp. 10343-10439. https://doi.org/10.1073/pnas.1811940115

Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model. / Karamitros, Timokratis; Hurst, Tara; Marchi, Emanuele et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 41, 09.10.2018, p. 10343-10439.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

AU - Karamitros, Timokratis

AU - Hurst, Tara

AU - Marchi, Emanuele

AU - Karamichali, Eirini

AU - Georgopoulou, Urania

AU - Mentis, Andreas

AU - Riepsaame, Joey

AU - Lin, Audrey

AU - Paraskevis, Dimitrios

AU - Hatzakis, Angelos

AU - McLauchlan, John

AU - Katzourakis, Aris

AU - Magiorkinis, Gkikas

N1 - Funding Information: ACKNOWLEDGMENTS. We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC_UU_12014/1). A.K. was funded by the Royal Society. Funding Information: We thank Paul Klenerman for critical reading of the manuscript. We wish to acknowledge the role of the HCV Research UK Biobank (Award C0365) in collecting and making available samples and data for this publication. The study has been supported by Medical Research Council UK (Project MR/K010565/1). J.M. was supported by an MRC Award (MC_UU_12014/1). A.K. was funded by the Royal Society. Publisher Copyright: © 2018 National Academy of Sciences. All Rights Reserved.

PY - 2018/10/9

Y1 - 2018/10/9

KW - Addiction

KW - Endogenous retrovirus

KW - HERV-K HML-2

KW - Persons who inject drugs

KW - RASGRF2

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 41

ER -

Karamitros T, Hurst T, Marchi E, Karamichali E, Georgopoulou U, Mentis A et al. Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model. Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 9;115(41):10343-10439. doi: 10.1073/pnas.1811940115

Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

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Keywords

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