Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates

Andrea M. Santangelo; Steve J. Sawiak; Tim Fryer; Young Hong; Yoshiro Shiba; Hannah F. Clarke; Patrick J. Riss; Valentina Ferrari; Roger Tait; John Suckling; Franklin I. Aigbirhio; Angela C. Roberts

doi:10.1073/pnas.1902087116

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates

Andrea M. Santangelo^*, Steve J. Sawiak, Tim Fryer, Young Hong, Yoshiro Shiba, Hannah F. Clarke, Patrick J. Riss, Valentina Ferrari, Roger Tait, John Suckling, Franklin I. Aigbirhio, Angela C. Roberts

^*Corresponding author for this work

University of Cambridge

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

Original language	English
Pages (from-to)	14761-14768
Number of pages	8
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	116
Issue number	29
DOIs	https://doi.org/10.1073/pnas.1902087116
Publication status	Published (VoR) - 2019

Funding

ACKNOWLEDGMENTS. This work was supported by Medical Research Council (MRC) Programme Grant MR/M023990/1 (to A.C.R.). S.J.S. was supported by the Behavioural and Clinical Neuroscience Institute, supported jointly by the Wellcome Trust and MRC. P.J.R. and the development of the PET ligand were supported by MRC Grant G0900903 (to F.I.A. and A.C.R.).

Keywords

Insula cortex
Receptor | anxiety
Serotonin 2A
Serotonin transporter polymorphism

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10.1073/pnas.1902087116

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Santangelo, A. M., Sawiak, S. J., Fryer, T., Hong, Y., Shiba, Y., Clarke, H. F., Riss, P. J., Ferrari, V., Tait, R., Suckling, J., Aigbirhio, F. I., & Roberts, A. C. (2019). Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates. Proceedings of the National Academy of Sciences of the United States of America, 116(29), 14761-14768. https://doi.org/10.1073/pnas.1902087116

@article{aae563afef68461caa5077543ef02252,

title = "Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates",

keywords = "Insula cortex, Receptor | anxiety, Serotonin 2A, Serotonin transporter polymorphism",

author = "Santangelo, \{Andrea M.\} and Sawiak, \{Steve J.\} and Tim Fryer and Young Hong and Yoshiro Shiba and Clarke, \{Hannah F.\} and Riss, \{Patrick J.\} and Valentina Ferrari and Roger Tait and John Suckling and Aigbirhio, \{Franklin I.\} and Roberts, \{Angela C.\}",

note = "Funding Information: ACKNOWLEDGMENTS. This work was supported by Medical Research Council (MRC) Programme Grant MR/M023990/1 (to A.C.R.). S.J.S. was supported by the Behavioural and Clinical Neuroscience Institute, supported jointly by the Wellcome Trust and MRC. P.J.R. and the development of the PET ligand were supported by MRC Grant G0900903 (to F.I.A. and A.C.R.). Publisher Copyright: {\textcopyright} 2019 National Academy of Sciences. All rights reserved.",

year = "2019",

doi = "10.1073/pnas.1902087116",

language = "English",

volume = "116",

pages = "14761--14768",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "29",

}

Santangelo, AM, Sawiak, SJ, Fryer, T, Hong, Y, Shiba, Y, Clarke, HF, Riss, PJ, Ferrari, V, Tait, R, Suckling, J, Aigbirhio, FI & Roberts, AC 2019, 'Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 29, pp. 14761-14768. https://doi.org/10.1073/pnas.1902087116

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates. / Santangelo, Andrea M.; Sawiak, Steve J.; Fryer, Tim et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 29, 2019, p. 14761-14768.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates

AU - Santangelo, Andrea M.

AU - Sawiak, Steve J.

AU - Fryer, Tim

AU - Hong, Young

AU - Shiba, Yoshiro

AU - Clarke, Hannah F.

AU - Riss, Patrick J.

AU - Ferrari, Valentina

AU - Tait, Roger

AU - Suckling, John

AU - Aigbirhio, Franklin I.

AU - Roberts, Angela C.

N1 - Funding Information: ACKNOWLEDGMENTS. This work was supported by Medical Research Council (MRC) Programme Grant MR/M023990/1 (to A.C.R.). S.J.S. was supported by the Behavioural and Clinical Neuroscience Institute, supported jointly by the Wellcome Trust and MRC. P.J.R. and the development of the PET ligand were supported by MRC Grant G0900903 (to F.I.A. and A.C.R.). Publisher Copyright: © 2019 National Academy of Sciences. All rights reserved.

PY - 2019

Y1 - 2019

KW - Insula cortex

KW - Receptor | anxiety

KW - Serotonin 2A

KW - Serotonin transporter polymorphism

UR - https://www.scopus.com/pages/publications/85069051852

UR - https://www.scopus.com/inward/citedby.url?scp=85069051852&partnerID=8YFLogxK

U2 - 10.1073/pnas.1902087116

DO - 10.1073/pnas.1902087116

M3 - Article

C2 - 31266890

AN - SCOPUS:85069051852

SN - 0027-8424

VL - 116

SP - 14761

EP - 14768

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 29

ER -

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates

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