Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang; Jan Kudlacek; Jaroslav Hlinka; Jan Chvojka; Michal Hadrava; Vojtech Kumpost; Andrew D. Powell; Radek Janca; Matias I. Maturana; Philippa J. Karoly; Dean R. Freestone; Mark J. Cook; Milan Palus; Jakub Otahal; John G. R. Jefferys; Premysl Jiruska

doi:10.1038/s41593-018-0278-y

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang
, Jan Kudlacek
, Jaroslav Hlinka
, Jan Chvojka
, Michal Hadrava
, Vojtech Kumpost
, Andrew D. Powell
, Radek Janca
, Matias I. Maturana
, Philippa J. Karoly
, Dean R. Freestone
, Mark J. Cook
, Milan Palus
, Jakub Otahal
, John G. R. Jefferys
, Premysl Jiruska

Research output: Contribution to journal › Article › peer-review

91 Citations (SciVal)

Original language	English
Pages (from-to)	1742-1752
Number of pages	11
Journal	Nature Neuroscience
Volume	21
Issue number	12
DOIs	https://doi.org/10.1038/s41593-018-0278-y
Publication status	Published (VoR) - 26 Nov 2018

Funding

This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.).

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https://www.nature.com/articles/s41593-018-0278-y

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Chang, W.-C., Kudlacek, J., Hlinka, J., Chvojka, J., Hadrava, M., Kumpost, V., Powell, A. D., Janca, R., Maturana, M. I., Karoly, P. J., Freestone, D. R., Cook, M. J., Palus, M., Otahal, J., Jefferys, J. G. R., & Jiruska, P. (2018). Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations. Nature Neuroscience, 21(12), 1742-1752. https://doi.org/10.1038/s41593-018-0278-y

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title = "Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations",

author = "Wei-Chih Chang and Jan Kudlacek and Jaroslav Hlinka and Jan Chvojka and Michal Hadrava and Vojtech Kumpost and Powell, \{Andrew D.\} and Radek Janca and Maturana, \{Matias I.\} and Karoly, \{Philippa J.\} and Freestone, \{Dean R.\} and Cook, \{Mark J.\} and Milan Palus and Jakub Otahal and Jefferys, \{John G. R.\} and Premysl Jiruska",

note = "Funding Information: This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.). Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2018",

month = nov,

day = "26",

doi = "10.1038/s41593-018-0278-y",

language = "English",

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Chang, W-C, Kudlacek, J, Hlinka, J, Chvojka, J, Hadrava, M, Kumpost, V, Powell, AD, Janca, R, Maturana, MI, Karoly, PJ, Freestone, DR, Cook, MJ, Palus, M, Otahal, J, Jefferys, JGR & Jiruska, P 2018, 'Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations', Nature Neuroscience, vol. 21, no. 12, pp. 1742-1752. https://doi.org/10.1038/s41593-018-0278-y

TY - JOUR

T1 - Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

AU - Chang, Wei-Chih

AU - Kudlacek, Jan

AU - Hlinka, Jaroslav

AU - Chvojka, Jan

AU - Hadrava, Michal

AU - Kumpost, Vojtech

AU - Powell, Andrew D.

AU - Janca, Radek

AU - Maturana, Matias I.

AU - Karoly, Philippa J.

AU - Freestone, Dean R.

AU - Cook, Mark J.

AU - Palus, Milan

AU - Otahal, Jakub

AU - Jefferys, John G. R.

AU - Jiruska, Premysl

N1 - Funding Information: This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.). Publisher Copyright: © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2018/11/26

Y1 - 2018/11/26

UR - https://www.scopus.com/pages/publications/85057290648

UR - https://www.scopus.com/pages/publications/85057290648#tab=citedBy

U2 - 10.1038/s41593-018-0278-y

DO - 10.1038/s41593-018-0278-y

M3 - Article

C2 - 30482946

SN - 1097-6256

VL - 21

SP - 1742

EP - 1752

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 12

ER -

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

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