Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang; Jan Kudlacek; Jaroslav Hlinka; Jan Chvojka; Michal Hadrava; Vojtech Kumpost; Andrew D. Powell; Radek Janca; Matias I. Maturana; Philippa J. Karoly; Dean R. Freestone; Mark J. Cook; Milan Palus; Jakub Otahal; John G. R. Jefferys; Premysl Jiruska

doi:10.1038/s41593-018-0278-y

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D. Powell, Radek Janca, Matias I. Maturana, Philippa J. Karoly, Dean R. Freestone, Mark J. Cook, Milan Palus, Jakub Otahal, John G. R. Jefferys, Premysl Jiruska

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84 Citations (SciVal)

Original language	English
Pages (from-to)	1742-1752
Number of pages	11
Journal	Nature Neuroscience
Volume	21
Issue number	12
DOIs	https://doi.org/10.1038/s41593-018-0278-y
Publication status	Published (VoR) - 26 Nov 2018

Funding

This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.).

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Chang, W.-C., Kudlacek, J., Hlinka, J., Chvojka, J., Hadrava, M., Kumpost, V., Powell, A. D., Janca, R., Maturana, M. I., Karoly, P. J., Freestone, D. R., Cook, M. J., Palus, M., Otahal, J., Jefferys, J. G. R., & Jiruska, P. (2018). Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations. Nature Neuroscience, 21(12), 1742-1752. https://doi.org/10.1038/s41593-018-0278-y

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title = "Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations",

author = "Wei-Chih Chang and Jan Kudlacek and Jaroslav Hlinka and Jan Chvojka and Michal Hadrava and Vojtech Kumpost and Powell, \{Andrew D.\} and Radek Janca and Maturana, \{Matias I.\} and Karoly, \{Philippa J.\} and Freestone, \{Dean R.\} and Cook, \{Mark J.\} and Milan Palus and Jakub Otahal and Jefferys, \{John G. R.\} and Premysl Jiruska",

note = "Funding Information: This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.). Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2018",

month = nov,

day = "26",

doi = "10.1038/s41593-018-0278-y",

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Chang, W-C, Kudlacek, J, Hlinka, J, Chvojka, J, Hadrava, M, Kumpost, V, Powell, AD, Janca, R, Maturana, MI, Karoly, PJ, Freestone, DR, Cook, MJ, Palus, M, Otahal, J, Jefferys, JGR & Jiruska, P 2018, 'Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations', Nature Neuroscience, vol. 21, no. 12, pp. 1742-1752. https://doi.org/10.1038/s41593-018-0278-y

TY - JOUR

T1 - Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

AU - Chang, Wei-Chih

AU - Kudlacek, Jan

AU - Hlinka, Jaroslav

AU - Chvojka, Jan

AU - Hadrava, Michal

AU - Kumpost, Vojtech

AU - Powell, Andrew D.

AU - Janca, Radek

AU - Maturana, Matias I.

AU - Karoly, Philippa J.

AU - Freestone, Dean R.

AU - Cook, Mark J.

AU - Palus, Milan

AU - Otahal, Jakub

AU - Jefferys, John G. R.

AU - Jiruska, Premysl

N1 - Funding Information: This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.). Publisher Copyright: © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2018/11/26

Y1 - 2018/11/26

UR - https://www.scopus.com/pages/publications/85057290648

UR - https://www.scopus.com/inward/citedby.url?scp=85057290648&partnerID=8YFLogxK

U2 - 10.1038/s41593-018-0278-y

DO - 10.1038/s41593-018-0278-y

M3 - Article

C2 - 30482946

SN - 1097-6256

VL - 21

SP - 1742

EP - 1752

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 12

ER -

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

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