Machine learning in metastatic cancer research: Potentials, possibilities, and prospects

Olutomilayo Olayemi Petinrin, Faisal Saeed, Muhammad Toseef, Zhe Liu, Shadi Basurra, Ibukun Omotayo Muyide, Xiangtao Li, Ka-Chun Wong*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (SciVal)
    Original languageEnglish
    Pages (from-to)2454-2470
    Number of pages17
    JournalComputational and Structural Biotechnology Journal
    Volume21
    Issue number2023
    DOIs
    Publication statusPublished (VoR) - 29 Mar 2023

    Funding

    Side-Out Foundation Metastatic Breast Cancer Database captures data from studies sponsored by the foundation. The database with clinical trial numbers (NCT01074814, NCT01919749, NCT03195192) contains more than 700 data fields. It consists of NGS-based whole/targeted exome sequencing generated genomic data, RNA microarray or RNA Seq generated transcript analysis data, Reverse Phase Protein Microarray (RPPA) generated phosphoproteomic data. Patients are de-identified, and information such as treatment history, demographics, pathological and clinical information, information about metastatic lesions, and outcome data are collected during the trials.

    Keywords

    • Cancer metastasis; Data inequality; Deep learning; Early detection; Machine learning; Metastatic cancer

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