Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

Youming Zhang; Thanushiyan Poobalasingam; Laura L. Yates; Simone A. Walker; Martin S. Taylor; Lauren Chessum; Jackie Harrison; Loukia Tsaprouni; Ian M. Adcock; Clare M. Lloyd; William O. Cookson; Miriam F. Moffatt; Charlotte H. Dean

doi:10.1242/dmm.031369

Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

Youming Zhang
, Thanushiyan Poobalasingam
, Laura L. Yates
, Simone A. Walker
, Martin S. Taylor
, Lauren Chessum
, Jackie Harrison
, Loukia Tsaprouni
, Ian M. Adcock
, Clare M. Lloyd
, William O. Cookson
, Miriam F. Moffatt
, Charlotte H. Dean^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Original language	English
Article number	dmm031369
Journal	DMM Disease Models and Mechanisms
Volume	11
Issue number	1
DOIs	https://doi.org/10.1242/dmm.031369
Publication status	Published (VoR) - Jan 2018

Funding

This work was supported by the Wellcome Trust (WT 077959 and WT096964; Senior Investigator Award to W.O.C. and M.F.M.), the Medical Research Council, the National Heart and Lung Institute (C.H.D.) and Research Councils UK (Research Councils UK Fellowship to Y.Z.). C.H.D. was also supported by core funding from MRC Harwell. I.M.A. was supported by the Innovative Medicines Initiative Joint Undertaking (IMI-JU) programme U-BIOPRED (EU grant number 115010).

Keywords

Airway resistance
Asthma
DPP10
IgE
Point mutation

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10.1242/dmm.031369

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Zhang, Y., Poobalasingam, T., Yates, L. L., Walker, S. A., Taylor, M. S., Chessum, L., Harrison, J., Tsaprouni, L., Adcock, I. M., Lloyd, C. M., Cookson, W. O., Moffatt, M. F., & Dean, C. H. (2018). Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. DMM Disease Models and Mechanisms, 11(1), Article dmm031369. https://doi.org/10.1242/dmm.031369

@article{e07e97db6345433fb8e8bfb3542848aa,

title = "Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma",

keywords = "Airway resistance, Asthma, DPP10, IgE, Point mutation",

author = "Youming Zhang and Thanushiyan Poobalasingam and Yates, \{Laura L.\} and Walker, \{Simone A.\} and Taylor, \{Martin S.\} and Lauren Chessum and Jackie Harrison and Loukia Tsaprouni and Adcock, \{Ian M.\} and Lloyd, \{Clare M.\} and Cookson, \{William O.\} and Moffatt, \{Miriam F.\} and Dean, \{Charlotte H.\}",

note = "Funding Information: This work was supported by the Wellcome Trust (WT 077959 and WT096964; Senior Investigator Award to W.O.C. and M.F.M.), the Medical Research Council, the National Heart and Lung Institute (C.H.D.) and Research Councils UK (Research Councils UK Fellowship to Y.Z.). C.H.D. was also supported by core funding from MRC Harwell. I.M.A. was supported by the Innovative Medicines Initiative Joint Undertaking (IMI-JU) programme U-BIOPRED (EU grant number 115010). Publisher Copyright: {\textcopyright} 2018. Published by The Company of Biologists Ltd.",

year = "2018",

month = jan,

doi = "10.1242/dmm.031369",

language = "English",

volume = "11",

journal = "DMM Disease Models and Mechanisms",

issn = "1754-8403",

publisher = "The Company of Biologists",

number = "1",

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Zhang, Y, Poobalasingam, T, Yates, LL, Walker, SA, Taylor, MS, Chessum, L, Harrison, J, Tsaprouni, L, Adcock, IM, Lloyd, CM, Cookson, WO, Moffatt, MF & Dean, CH 2018, 'Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma', DMM Disease Models and Mechanisms, vol. 11, no. 1, dmm031369. https://doi.org/10.1242/dmm.031369

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T1 - Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

AU - Zhang, Youming

AU - Poobalasingam, Thanushiyan

AU - Yates, Laura L.

AU - Walker, Simone A.

AU - Taylor, Martin S.

AU - Chessum, Lauren

AU - Harrison, Jackie

AU - Tsaprouni, Loukia

AU - Adcock, Ian M.

AU - Lloyd, Clare M.

AU - Cookson, William O.

AU - Moffatt, Miriam F.

AU - Dean, Charlotte H.

N1 - Funding Information: This work was supported by the Wellcome Trust (WT 077959 and WT096964; Senior Investigator Award to W.O.C. and M.F.M.), the Medical Research Council, the National Heart and Lung Institute (C.H.D.) and Research Councils UK (Research Councils UK Fellowship to Y.Z.). C.H.D. was also supported by core funding from MRC Harwell. I.M.A. was supported by the Innovative Medicines Initiative Joint Undertaking (IMI-JU) programme U-BIOPRED (EU grant number 115010). Publisher Copyright: © 2018. Published by The Company of Biologists Ltd.

PY - 2018/1

Y1 - 2018/1

KW - Airway resistance

KW - Asthma

KW - DPP10

KW - IgE

KW - Point mutation

UR - https://www.scopus.com/pages/publications/85041693135

UR - https://www.scopus.com/pages/publications/85041693135#tab=citedBy

U2 - 10.1242/dmm.031369

DO - 10.1242/dmm.031369

M3 - Article

C2 - 29361513

AN - SCOPUS:85041693135

SN - 1754-8403

VL - 11

JO - DMM Disease Models and Mechanisms

JF - DMM Disease Models and Mechanisms

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M1 - dmm031369

ER -

Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

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