Mapping cis-and trans-regulatory effects across multiple tissues in twins

Elin Grundberg; Kerrin S. Small; Åsa K. Hedman; Alexandra C. Nica; Alfonso Buil; Sarah Keildson; Jordana T. Bell; Tsun Po Yang; Eshwar Meduri; Amy Barrett; James Nisbett; Magdalena Sekowska; Alicja Wilk; So Youn Shin; Daniel Glass; Mary Travers; Josine L. Min; Sue Ring; Karen Ho; Gudmar Thorleifsson; Augustine Kong; Unnur Thorsteindottir; Chrysanthi Ainali; Antigone S. Dimas; Neelam Hassanali; Catherine Ingle; David Knowles; Maria Krestyaninova; Christopher E. Lowe; Paola Di Meglio; Stephen B. Montgomery; Leopold Parts; Simon Potter; Gabriela Surdulescu; Loukia Tsaprouni; Sophia Tsoka; Veronique Bataille; Richard Durbin; Frank O. Nestle; Stephen O'Rahilly; Nicole Soranzo; Cecilia M. Lindgren; Krina T. Zondervan; Kourosh R. Ahmadi; Eric E. Schadt; Kari Stefansson; George Davey Smith; Mark I. McCarthy; Panos Deloukas; Emmanouil T. Dermitzakis; Tim D. Spector

doi:10.1038/ng.2394

Mapping cis-and trans-regulatory effects across multiple tissues in twins

Elin Grundberg
, Kerrin S. Small
, Åsa K. Hedman
, Alexandra C. Nica
, Alfonso Buil
, Sarah Keildson
, Jordana T. Bell
, Tsun Po Yang
, Eshwar Meduri
, Amy Barrett
, James Nisbett
, Magdalena Sekowska
, Alicja Wilk
, So Youn Shin
, Daniel Glass
, Mary Travers
, Josine L. Min
, Sue Ring
, Karen Ho
, Gudmar Thorleifsson

Augustine Kong, Unnur Thorsteindottir, Chrysanthi Ainali, Antigone S. Dimas, Neelam Hassanali, Catherine Ingle, David Knowles, Maria Krestyaninova, Christopher E. Lowe, Paola Di Meglio, Stephen B. Montgomery, Leopold Parts, Simon Potter, Gabriela Surdulescu, Loukia Tsaprouni, Sophia Tsoka, Veronique Bataille, Richard Durbin, Frank O. Nestle, Stephen O'Rahilly, Nicole Soranzo, Cecilia M. Lindgren, Krina T. Zondervan, Kourosh R. Ahmadi, Eric E. Schadt, Kari Stefansson, George Davey Smith, Mark I. McCarthy^*, Panos Deloukas, Emmanouil T. Dermitzakis, Tim D. Spector

^*Corresponding author for this work

Wellcome Sanger Institute
King's College London
University of Oxford
University of Geneva
University of Bristol
deCODE Genetics
University of Iceland
University of Cambridge
European Molecular Biology Laboratory
Cambridge University Hospitals NHS Foundation Trust
Stanford University
Icahn School of Medicine at Mount Sinai
Oxford University Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

589 Citations (SciVal)

Original language	English
Pages (from-to)	1084-1089
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	10
DOIs	https://doi.org/10.1038/ng.2394
Publication status	Published (VoR) - Oct 2012

Funding

The MuTHER Study was funded by a program grant from the Wellcome Trust (081917/Z/07/Z) and by core funding for the Wellcome Trust Centre for Human Genetics (090532). Additional funding came from the European Community’s Seventh Framework Programme (FP7/2007-2013), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Swiss National Science Foundation and the NCCR Frontiers in Genetics, the Louis-Jeantet Foundation and a US National Institutes of Health–NIMH grant (GTEx project). Additional details on the funding for the participating studies and investigators are provided in the Supplementary Note.

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Grundberg, E., Small, K. S., Hedman, Å. K., Nica, A. C., Buil, A., Keildson, S., Bell, J. T., Yang, T. P., Meduri, E., Barrett, A., Nisbett, J., Sekowska, M., Wilk, A., Shin, S. Y., Glass, D., Travers, M., Min, J. L., Ring, S., Ho, K., ... Spector, T. D. (2012). Mapping cis-and trans-regulatory effects across multiple tissues in twins. Nature Genetics, 44(10), 1084-1089. https://doi.org/10.1038/ng.2394

@article{9b1e9c566ac54d1ba1a920c3bc45cdff,

title = "Mapping cis-and trans-regulatory effects across multiple tissues in twins",

author = "Elin Grundberg and Small, \{Kerrin S.\} and Hedman, \{{\AA}sa K.\} and Nica, \{Alexandra C.\} and Alfonso Buil and Sarah Keildson and Bell, \{Jordana T.\} and Yang, \{Tsun Po\} and Eshwar Meduri and Amy Barrett and James Nisbett and Magdalena Sekowska and Alicja Wilk and Shin, \{So Youn\} and Daniel Glass and Mary Travers and Min, \{Josine L.\} and Sue Ring and Karen Ho and Gudmar Thorleifsson and Augustine Kong and Unnur Thorsteindottir and Chrysanthi Ainali and Dimas, \{Antigone S.\} and Neelam Hassanali and Catherine Ingle and David Knowles and Maria Krestyaninova and Lowe, \{Christopher E.\} and \{Di Meglio\}, Paola and Montgomery, \{Stephen B.\} and Leopold Parts and Simon Potter and Gabriela Surdulescu and Loukia Tsaprouni and Sophia Tsoka and Veronique Bataille and Richard Durbin and Nestle, \{Frank O.\} and Stephen O'Rahilly and Nicole Soranzo and Lindgren, \{Cecilia M.\} and Zondervan, \{Krina T.\} and Ahmadi, \{Kourosh R.\} and Schadt, \{Eric E.\} and Kari Stefansson and Smith, \{George Davey\} and McCarthy, \{Mark I.\} and Panos Deloukas and Dermitzakis, \{Emmanouil T.\} and Spector, \{Tim D.\}",

note = "Funding Information: The MuTHER Study was funded by a program grant from the Wellcome Trust (081917/Z/07/Z) and by core funding for the Wellcome Trust Centre for Human Genetics (090532). Additional funding came from the European Community{\textquoteright}s Seventh Framework Programme (FP7/2007-2013), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Swiss National Science Foundation and the NCCR Frontiers in Genetics, the Louis-Jeantet Foundation and a US National Institutes of Health–NIMH grant (GTEx project). Additional details on the funding for the participating studies and investigators are provided in the Supplementary Note.",

year = "2012",

month = oct,

doi = "10.1038/ng.2394",

language = "English",

volume = "44",

pages = "1084--1089",

journal = "Nature Genetics",

issn = "1061-4036",

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number = "10",

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Grundberg, E, Small, KS, Hedman, ÅK, Nica, AC, Buil, A, Keildson, S, Bell, JT, Yang, TP, Meduri, E, Barrett, A, Nisbett, J, Sekowska, M, Wilk, A, Shin, SY, Glass, D, Travers, M, Min, JL, Ring, S, Ho, K, Thorleifsson, G, Kong, A, Thorsteindottir, U, Ainali, C, Dimas, AS, Hassanali, N, Ingle, C, Knowles, D, Krestyaninova, M, Lowe, CE, Di Meglio, P, Montgomery, SB, Parts, L, Potter, S, Surdulescu, G, Tsaprouni, L, Tsoka, S, Bataille, V, Durbin, R, Nestle, FO, O'Rahilly, S, Soranzo, N, Lindgren, CM, Zondervan, KT, Ahmadi, KR, Schadt, EE, Stefansson, K, Smith, GD, McCarthy, MI, Deloukas, P, Dermitzakis, ET & Spector, TD 2012, 'Mapping cis-and trans-regulatory effects across multiple tissues in twins', Nature Genetics, vol. 44, no. 10, pp. 1084-1089. https://doi.org/10.1038/ng.2394

TY - JOUR

T1 - Mapping cis-and trans-regulatory effects across multiple tissues in twins

AU - Grundberg, Elin

AU - Small, Kerrin S.

AU - Hedman, Åsa K.

AU - Nica, Alexandra C.

AU - Buil, Alfonso

AU - Keildson, Sarah

AU - Bell, Jordana T.

AU - Yang, Tsun Po

AU - Meduri, Eshwar

AU - Barrett, Amy

AU - Nisbett, James

AU - Sekowska, Magdalena

AU - Wilk, Alicja

AU - Shin, So Youn

AU - Glass, Daniel

AU - Travers, Mary

AU - Min, Josine L.

AU - Ring, Sue

AU - Ho, Karen

AU - Thorleifsson, Gudmar

AU - Kong, Augustine

AU - Thorsteindottir, Unnur

AU - Ainali, Chrysanthi

AU - Dimas, Antigone S.

AU - Hassanali, Neelam

AU - Ingle, Catherine

AU - Knowles, David

AU - Krestyaninova, Maria

AU - Lowe, Christopher E.

AU - Di Meglio, Paola

AU - Montgomery, Stephen B.

AU - Parts, Leopold

AU - Potter, Simon

AU - Surdulescu, Gabriela

AU - Tsaprouni, Loukia

AU - Tsoka, Sophia

AU - Bataille, Veronique

AU - Durbin, Richard

AU - Nestle, Frank O.

AU - O'Rahilly, Stephen

AU - Soranzo, Nicole

AU - Lindgren, Cecilia M.

AU - Zondervan, Krina T.

AU - Ahmadi, Kourosh R.

AU - Schadt, Eric E.

AU - Stefansson, Kari

AU - Smith, George Davey

AU - McCarthy, Mark I.

AU - Deloukas, Panos

AU - Dermitzakis, Emmanouil T.

AU - Spector, Tim D.

N1 - Funding Information: The MuTHER Study was funded by a program grant from the Wellcome Trust (081917/Z/07/Z) and by core funding for the Wellcome Trust Centre for Human Genetics (090532). Additional funding came from the European Community’s Seventh Framework Programme (FP7/2007-2013), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Swiss National Science Foundation and the NCCR Frontiers in Genetics, the Louis-Jeantet Foundation and a US National Institutes of Health–NIMH grant (GTEx project). Additional details on the funding for the participating studies and investigators are provided in the Supplementary Note.

PY - 2012/10

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DO - 10.1038/ng.2394

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AN - SCOPUS:84866871814

SN - 1061-4036

VL - 44

SP - 1084

EP - 1089

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Mapping cis-and trans-regulatory effects across multiple tissues in twins

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