Metabolomic markers reveal novel pathways of ageing and early development in human populations

Cristina Menni; Gabriella Kastenmüller; Ann Kristin Petersen; Jordana T. Bell; Maria Psatha; Pei Chien Tsai; Christian Gieger; Holger Schulz; Idil Erte; Sally John; M. Julia Brosnan; Scott G. Wilson; Loukia Tsaprouni; Ee Mun Lim; Bronwyn Stuckey; Panos Deloukas; Robert Mohney; Karsten Suhre; Tim D. Spector; Ana M. Valdes

doi:10.1093/ije/dyt094

Metabolomic markers reveal novel pathways of ageing and early development in human populations

Cristina Menni, Gabriella Kastenmüller, Ann Kristin Petersen, Jordana T. Bell, Maria Psatha, Pei Chien Tsai, Christian Gieger, Holger Schulz, Idil Erte, Sally John, M. Julia Brosnan, Scott G. Wilson, Loukia Tsaprouni, Ee Mun Lim, Bronwyn Stuckey, Panos Deloukas, Robert Mohney, Karsten Suhre, Tim D. Spector, Ana M. Valdes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

249 Citations (SciVal)

Original language	English
Article number	dyt094
Pages (from-to)	1111-1119
Number of pages	9
Journal	International Journal of Epidemiology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1093/ije/dyt094
Publication status	Published (VoR) - Aug 2013

Funding

This work was supported by: European Community’s Seventh Framework programme (FP7/2007-2013) EurHEALTH Ageing HEALTH-F2-2011-277849; Pfizer; the Wellcome Trust European Community’s Seventh Framework Programme (FP7/2007-2013 to TwinsUK); ENGAGE project grant agreement (HEALTH-F4-2007-201413 to TwinsUK); the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas NHS Foundation Trust in partnership with King’s College London (to TwinsUK); ERC Advanced Principal Investigator award to T.D.S.; the Wellcome Trust (Grant 098051 to P.D. and L.T.); the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria to the Helmholtz Zentrum München-German Research Center for Environmental Health and Munich Center of Health Sciences (MC Health), Ludwig-Maximilians-Universität, as part of LMU innovative and KORA; the Competence Network ASCONET, specifically the subnetwork COSYCONET, and the KORA-Age project funded by the German Federal Ministry of Education and Research to KORA. K.S. is supported by ‘Biomedical Research Program’ funds at Weill Cornell Medical College in Qatar, a program funded by the Qatar Foundation. The statements made herein are solely the responsibility of the authors.

Keywords

Ageing
Birthweight
Developmental origins of health and disease
Epigenetics
Metabolomics
Twin studies

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Menni, C., Kastenmüller, G., Petersen, A. K., Bell, J. T., Psatha, M., Tsai, P. C., Gieger, C., Schulz, H., Erte, I., John, S., Brosnan, M. J., Wilson, S. G., Tsaprouni, L., Lim, E. M., Stuckey, B., Deloukas, P., Mohney, R., Suhre, K., Spector, T. D., & Valdes, A. M. (2013). Metabolomic markers reveal novel pathways of ageing and early development in human populations. International Journal of Epidemiology, 42(4), 1111-1119. Article dyt094. https://doi.org/10.1093/ije/dyt094

@article{f19a541ddd5c43c1ab2070bbe321a6a4,

title = "Metabolomic markers reveal novel pathways of ageing and early development in human populations",

keywords = "Ageing, Birthweight, Developmental origins of health and disease, Epigenetics, Metabolomics, Twin studies",

author = "Cristina Menni and Gabriella Kastenm{\"u}ller and Petersen, \{Ann Kristin\} and Bell, \{Jordana T.\} and Maria Psatha and Tsai, \{Pei Chien\} and Christian Gieger and Holger Schulz and Idil Erte and Sally John and Brosnan, \{M. Julia\} and Wilson, \{Scott G.\} and Loukia Tsaprouni and Lim, \{Ee Mun\} and Bronwyn Stuckey and Panos Deloukas and Robert Mohney and Karsten Suhre and Spector, \{Tim D.\} and Valdes, \{Ana M.\}",

note = "Funding Information: This work was supported by: European Community{\textquoteright}s Seventh Framework programme (FP7/2007-2013) EurHEALTH Ageing HEALTH-F2-2011-277849; Pfizer; the Wellcome Trust European Community{\textquoteright}s Seventh Framework Programme (FP7/2007-2013 to TwinsUK); ENGAGE project grant agreement (HEALTH-F4-2007-201413 to TwinsUK); the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy{\textquoteright}s \& St Thomas NHS Foundation Trust in partnership with King{\textquoteright}s College London (to TwinsUK); ERC Advanced Principal Investigator award to T.D.S.; the Wellcome Trust (Grant 098051 to P.D. and L.T.); the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria to the Helmholtz Zentrum M{\"u}nchen-German Research Center for Environmental Health and Munich Center of Health Sciences (MC Health), Ludwig-Maximilians-Universit{\"a}t, as part of LMU innovative and KORA; the Competence Network ASCONET, specifically the subnetwork COSYCONET, and the KORA-Age project funded by the German Federal Ministry of Education and Research to KORA. K.S. is supported by {\textquoteleft}Biomedical Research Program{\textquoteright} funds at Weill Cornell Medical College in Qatar, a program funded by the Qatar Foundation. The statements made herein are solely the responsibility of the authors.",

year = "2013",

month = aug,

doi = "10.1093/ije/dyt094",

language = "English",

volume = "42",

pages = "1111--1119",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "4",

}

Menni, C, Kastenmüller, G, Petersen, AK, Bell, JT, Psatha, M, Tsai, PC, Gieger, C, Schulz, H, Erte, I, John, S, Brosnan, MJ, Wilson, SG, Tsaprouni, L, Lim, EM, Stuckey, B, Deloukas, P, Mohney, R, Suhre, K, Spector, TD & Valdes, AM 2013, 'Metabolomic markers reveal novel pathways of ageing and early development in human populations', International Journal of Epidemiology, vol. 42, no. 4, dyt094, pp. 1111-1119. https://doi.org/10.1093/ije/dyt094

TY - JOUR

T1 - Metabolomic markers reveal novel pathways of ageing and early development in human populations

AU - Menni, Cristina

AU - Kastenmüller, Gabriella

AU - Petersen, Ann Kristin

AU - Bell, Jordana T.

AU - Psatha, Maria

AU - Tsai, Pei Chien

AU - Gieger, Christian

AU - Schulz, Holger

AU - Erte, Idil

AU - John, Sally

AU - Brosnan, M. Julia

AU - Wilson, Scott G.

AU - Tsaprouni, Loukia

AU - Lim, Ee Mun

AU - Stuckey, Bronwyn

AU - Deloukas, Panos

AU - Mohney, Robert

AU - Suhre, Karsten

AU - Spector, Tim D.

AU - Valdes, Ana M.

N1 - Funding Information: This work was supported by: European Community’s Seventh Framework programme (FP7/2007-2013) EurHEALTH Ageing HEALTH-F2-2011-277849; Pfizer; the Wellcome Trust European Community’s Seventh Framework Programme (FP7/2007-2013 to TwinsUK); ENGAGE project grant agreement (HEALTH-F4-2007-201413 to TwinsUK); the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas NHS Foundation Trust in partnership with King’s College London (to TwinsUK); ERC Advanced Principal Investigator award to T.D.S.; the Wellcome Trust (Grant 098051 to P.D. and L.T.); the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria to the Helmholtz Zentrum München-German Research Center for Environmental Health and Munich Center of Health Sciences (MC Health), Ludwig-Maximilians-Universität, as part of LMU innovative and KORA; the Competence Network ASCONET, specifically the subnetwork COSYCONET, and the KORA-Age project funded by the German Federal Ministry of Education and Research to KORA. K.S. is supported by ‘Biomedical Research Program’ funds at Weill Cornell Medical College in Qatar, a program funded by the Qatar Foundation. The statements made herein are solely the responsibility of the authors.

PY - 2013/8

Y1 - 2013/8

KW - Ageing

KW - Birthweight

KW - Developmental origins of health and disease

KW - Epigenetics

KW - Metabolomics

KW - Twin studies

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UR - https://www.scopus.com/inward/citedby.url?scp=84882448950&partnerID=8YFLogxK

U2 - 10.1093/ije/dyt094

DO - 10.1093/ije/dyt094

M3 - Article

C2 - 23838602

AN - SCOPUS:84882448950

SN - 0300-5771

VL - 42

SP - 1111

EP - 1119

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 4

M1 - dyt094

ER -

Metabolomic markers reveal novel pathways of ageing and early development in human populations

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Keywords

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