Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

Sorcha Forde; Jamie D. Matthews; Leila Jahangiri; Liam C. Lee; Nina Prokoph; Tim I.M. Malcolm; Olivier T. Giger; Natalie Bell; Helen Blair; Aengus O'Marcaigh; Owen Smith; Lukas Kenner; Simon Bomken; Gladstone A.A. Burke; Suzanne D. Turner

doi:10.1111/bjh.17043

Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

Sorcha Forde, Jamie D. Matthews, Leila Jahangiri, Liam C. Lee, Nina Prokoph, Tim I.M. Malcolm, Olivier T. Giger, Natalie Bell, Helen Blair, Aengus O'Marcaigh, Owen Smith, Lukas Kenner, Simon Bomken, Gladstone A.A. Burke, Suzanne D. Turner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (SciVal)

Original language	English
Pages (from-to)	354-365
Number of pages	12
Journal	British Journal of Haematology
Volume	192
Issue number	2
DOIs	https://doi.org/10.1111/bjh.17043
Publication status	Published (VoR) - Jan 2021

Funding

We are grateful to Dave, Nic, Brenda and Matt for their support, courage and determination to put an end to childhood cancer in memory of Alex. SF, JDM, GAAB and SDT are supported with funding from the Alex Hulme Foundation. We thank the Cambridge NIHR BRC Cell Phenotyping Hub, Addenbrooke’s Hospital, Cambridge; Central Biomedical Services (CBS), Addenbrooke’s Hospital, Cambridge; Haematopathology and Oncology Diagnostic Service (HODS) Lab, Addenbrooke’s Hospital, Cambridge; and the Histology Lab, Department of Pathology, University of Cambridge. We are also extremely grateful to all the children and their parents who donated their tumour tissues for this study.

Keywords

B-cell lymphoma
Burkitt lymphoma
murine cancer models
patient derived xenograft
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10.1111/bjh.17043

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Forde, S., Matthews, J. D., Jahangiri, L., Lee, L. C., Prokoph, N., Malcolm, T. I. M., Giger, O. T., Bell, N., Blair, H., O'Marcaigh, A., Smith, O., Kenner, L., Bomken, S., Burke, G. A. A., & Turner, S. D. (2021). Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy. British Journal of Haematology, 192(2), 354-365. https://doi.org/10.1111/bjh.17043

@article{939169442d9249ce95d2e5e71a3f6f95,

title = "Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy",

keywords = "B-cell lymphoma, Burkitt lymphoma, murine cancer models, patient derived xenograft, relapse",

author = "Sorcha Forde and Matthews, \{Jamie D.\} and Leila Jahangiri and Lee, \{Liam C.\} and Nina Prokoph and Malcolm, \{Tim I.M.\} and Giger, \{Olivier T.\} and Natalie Bell and Helen Blair and Aengus O'Marcaigh and Owen Smith and Lukas Kenner and Simon Bomken and Burke, \{Gladstone A.A.\} and Turner, \{Suzanne D.\}",

note = "Funding Information: We are grateful to Dave, Nic, Brenda and Matt for their support, courage and determination to put an end to childhood cancer in memory of Alex. SF, JDM, GAAB and SDT are supported with funding from the Alex Hulme Foundation. We thank the Cambridge NIHR BRC Cell Phenotyping Hub, Addenbrooke{\textquoteright}s Hospital, Cambridge; Central Biomedical Services (CBS), Addenbrooke{\textquoteright}s Hospital, Cambridge; Haematopathology and Oncology Diagnostic Service (HODS) Lab, Addenbrooke{\textquoteright}s Hospital, Cambridge; and the Histology Lab, Department of Pathology, University of Cambridge. We are also extremely grateful to all the children and their parents who donated their tumour tissues for this study. Publisher Copyright: {\textcopyright} 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley \& Sons Ltd",

year = "2021",

month = jan,

doi = "10.1111/bjh.17043",

language = "English",

volume = "192",

pages = "354--365",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley",

number = "2",

}

Forde, S, Matthews, JD, Jahangiri, L, Lee, LC, Prokoph, N, Malcolm, TIM, Giger, OT, Bell, N, Blair, H, O'Marcaigh, A, Smith, O, Kenner, L, Bomken, S, Burke, GAA & Turner, SD 2021, 'Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy', British Journal of Haematology, vol. 192, no. 2, pp. 354-365. https://doi.org/10.1111/bjh.17043

TY - JOUR

T1 - Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

AU - Forde, Sorcha

AU - Matthews, Jamie D.

AU - Jahangiri, Leila

AU - Lee, Liam C.

AU - Prokoph, Nina

AU - Malcolm, Tim I.M.

AU - Giger, Olivier T.

AU - Bell, Natalie

AU - Blair, Helen

AU - O'Marcaigh, Aengus

AU - Smith, Owen

AU - Kenner, Lukas

AU - Bomken, Simon

AU - Burke, Gladstone A.A.

AU - Turner, Suzanne D.

N1 - Funding Information: We are grateful to Dave, Nic, Brenda and Matt for their support, courage and determination to put an end to childhood cancer in memory of Alex. SF, JDM, GAAB and SDT are supported with funding from the Alex Hulme Foundation. We thank the Cambridge NIHR BRC Cell Phenotyping Hub, Addenbrooke’s Hospital, Cambridge; Central Biomedical Services (CBS), Addenbrooke’s Hospital, Cambridge; Haematopathology and Oncology Diagnostic Service (HODS) Lab, Addenbrooke’s Hospital, Cambridge; and the Histology Lab, Department of Pathology, University of Cambridge. We are also extremely grateful to all the children and their parents who donated their tumour tissues for this study. Publisher Copyright: © 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd

PY - 2021/1

Y1 - 2021/1

KW - B-cell lymphoma

KW - Burkitt lymphoma

KW - murine cancer models

KW - patient derived xenograft

KW - relapse

UR - https://www.scopus.com/pages/publications/85090125689

UR - https://www.scopus.com/inward/citedby.url?scp=85090125689&partnerID=8YFLogxK

U2 - 10.1111/bjh.17043

DO - 10.1111/bjh.17043

M3 - Article

C2 - 32880915

AN - SCOPUS:85090125689

SN - 0007-1048

VL - 192

SP - 354

EP - 365

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

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