Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice

Giovanna R. Mallucci; Melanie D. White; Michael Farmer; Andrew Dickinson; Husna Khatun; Andrew D. Powell; Sebastian Brandner; John G.R. Jefferys; John Collinge

doi:10.1016/j.neuron.2007.01.005

Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice

Giovanna R. Mallucci^*, Melanie D. White, Michael Farmer, Andrew Dickinson, Husna Khatun, Andrew D. Powell, Sebastian Brandner, John G.R. Jefferys, John Collinge

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

236 Citations (SciVal)

Original language	English
Pages (from-to)	325-335
Number of pages	11
Journal	Neuron
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2007.01.005
Publication status	Published (VoR) - 1 Feb 2007

Funding

We thank Julie Underwood, Michelle Hainsworth, and Jackie Linehan for technical assistance; Ray Young for help with graphics; Sam Cooke and Tim Bliss (National Institute of Medical Research, Mill Hill) and Colm Cunningham (University of Southampton) for advice and guidance on behavioral testing. This work was funded by the Medical Research Council of Great Britain. The neurophysiological experiments were funded by a Physiological Society summer studentship (H.K.) and the Biotechnology and Biological Sciences Research Council (A.D.P.).

Keywords

HUMDISEASE
SYSNEURO

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10.1016/j.neuron.2007.01.005

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title = "Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice",

keywords = "HUMDISEASE, SYSNEURO",

author = "Mallucci, \{Giovanna R.\} and White, \{Melanie D.\} and Michael Farmer and Andrew Dickinson and Husna Khatun and Powell, \{Andrew D.\} and Sebastian Brandner and Jefferys, \{John G.R.\} and John Collinge",

note = "Funding Information: We thank Julie Underwood, Michelle Hainsworth, and Jackie Linehan for technical assistance; Ray Young for help with graphics; Sam Cooke and Tim Bliss (National Institute of Medical Research, Mill Hill) and Colm Cunningham (University of Southampton) for advice and guidance on behavioral testing. This work was funded by the Medical Research Council of Great Britain. The neurophysiological experiments were funded by a Physiological Society summer studentship (H.K.) and the Biotechnology and Biological Sciences Research Council (A.D.P.). ",

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AU - Mallucci, Giovanna R.

AU - White, Melanie D.

AU - Farmer, Michael

AU - Dickinson, Andrew

AU - Khatun, Husna

AU - Powell, Andrew D.

AU - Brandner, Sebastian

AU - Jefferys, John G.R.

AU - Collinge, John

N1 - Funding Information: We thank Julie Underwood, Michelle Hainsworth, and Jackie Linehan for technical assistance; Ray Young for help with graphics; Sam Cooke and Tim Bliss (National Institute of Medical Research, Mill Hill) and Colm Cunningham (University of Southampton) for advice and guidance on behavioral testing. This work was funded by the Medical Research Council of Great Britain. The neurophysiological experiments were funded by a Physiological Society summer studentship (H.K.) and the Biotechnology and Biological Sciences Research Council (A.D.P.).

PY - 2007/2/1

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Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice

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Keywords

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