@article{e9d5b99b3cfe42208d43c3d9334ccb06,
title = "The effectiveness of early prophylactic hypothermia in adult patients with traumatic brain injury: A systematic review and meta-analysis",
keywords = "Adult, Brain, Hypothermia, Injury, Mortality, Traumatic",
author = "Xiaoheng Wu and Yanling Tao and Lorraine Marsons and Phillip Dee and Dan Yu and Yumei Guan and Xiuhong Zhou",
note = "Funding Information: Therapeutic hypothermia, also known as targeted temperature management, is a procedure that adopts cooling strategies to purposely control the brain temperature at a targeted level. Hypothermia usually lasts for up to 7 d after the initial injury, and then the patient is rewarmed to normal temperature.16 It was first introduced as a neurological protection strategy in patients after cardiac arrest in the 1950s.17 Sufficient evidence has supported its safety and efficacy, and the National Institute for Health and Care Excellence recommends it as routine neuroprotection care for patients after cardiac arrest.18 The first randomised control trial (RCT) of applying therapeutic hypothermia to TBI suggested that cooling patients with TBI at 32 ?C?33 ?C for 48 h might improve their neurological prognosis.19 Since then, numerous studies have been conducted exploring the effects of therapeutic hypothermia in TBI.3,4, 20?24 Most compared hypothermia with normothermia (temperature maintained at 37 ?C), except for one that compared hypothermia with fever control (35.5?37 ?C).24 In this study, patients in the control group were maintained at 35.5?37 ?C for ethical reasons because such a temperature range was beneficial to patients who had cardiac arrest at that time.24This study received a funding from Longgang technological and innovation bureau of Shenzhen, China (LGKCYLWS2018000036). Funding Information: This study received a funding from Longgang technological and innovation bureau of Shenzhen , China ( LGKCYLWS2018000036 ). Publisher Copyright: {\textcopyright} 2020 Australian College of Critical Care Nurses Ltd",
year = "2021",
month = jan,
doi = "10.1016/j.aucc.2020.05.005",
language = "English",
volume = "34",
pages = "83--91",
journal = "Australian Critical Care",
issn = "1036-7314",
publisher = "Elsevier",
number = "1",
}