The effectiveness of early prophylactic hypothermia in adult patients with traumatic brain injury: A systematic review and meta-analysis

Xiaoheng Wu, Yanling Tao, Lorraine Marsons*, Phillip Dee, Dan Yu, Yumei Guan, Xiuhong Zhou

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    13 Citations (SciVal)
    Original languageEnglish
    Pages (from-to)83-91
    Number of pages9
    JournalAustralian Critical Care
    Volume34
    Issue number1
    DOIs
    Publication statusPublished (VoR) - Jan 2021

    Funding

    This study received a funding from Longgang technological and innovation bureau of Shenzhen , China ( LGKCYLWS2018000036 ). Therapeutic hypothermia, also known as targeted temperature management, is a procedure that adopts cooling strategies to purposely control the brain temperature at a targeted level. Hypothermia usually lasts for up to 7 d after the initial injury, and then the patient is rewarmed to normal temperature.16 It was first introduced as a neurological protection strategy in patients after cardiac arrest in the 1950s.17 Sufficient evidence has supported its safety and efficacy, and the National Institute for Health and Care Excellence recommends it as routine neuroprotection care for patients after cardiac arrest.18 The first randomised control trial (RCT) of applying therapeutic hypothermia to TBI suggested that cooling patients with TBI at 32 °C–33 °C for 48 h might improve their neurological prognosis.19 Since then, numerous studies have been conducted exploring the effects of therapeutic hypothermia in TBI.3,4, 20–24 Most compared hypothermia with normothermia (temperature maintained at 37 °C), except for one that compared hypothermia with fever control (35.5–37 °C).24 In this study, patients in the control group were maintained at 35.5–37 °C for ethical reasons because such a temperature range was beneficial to patients who had cardiac arrest at that time.24This study received a funding from Longgang technological and innovation bureau of Shenzhen, China (LGKCYLWS2018000036).

    FundersFunder number
    Longgang technological and innovation bureau of ShenzhenLGKCYLWS2018000036
    National Institute for Health and Care

      Keywords

      • Adult
      • Brain
      • Hypothermia
      • Injury
      • Mortality
      • Traumatic

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