The modulation of acute methamphetamine on the neuronal network oscillations in rat hippocampal CA3 area.

Yanan li, Xin'e Xie, Hang Xing, Xiang Yuan, Yuan Wang, Yikai Jin, Jiangang Wang, Martin Vreugdenhil, Ying Zhoa, Ruiling Zhang, Chengbiao Lu

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Gamma frequency oscillations (?, 30?100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain ? oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on ? oscillations. We explored the effects of multiple intracellular kinases on MA modulation of ? induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on ? oscillations, whereas none of them affected baseline ? strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of ? oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
    Original languageEnglish
    JournalFrontiers in Cellular Neurosceince
    Volume13
    Issue number277
    DOIs
    Publication statusPublished (VoR) - 21 Jun 2019

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