TY - JOUR
T1 - The modulation of acute methamphetamine on the neuronal network oscillations in rat hippocampal CA3 area.
AU - li, Yanan
AU - Xie, Xin'e
AU - Xing, Hang
AU - Yuan, Xiang
AU - Wang, Yuan
AU - Jin, Yikai
AU - Wang, Jiangang
AU - Vreugdenhil, Martin
AU - Zhoa, Ying
AU - Zhang, Ruiling
AU - Lu, Chengbiao
PY - 2019/6/21
Y1 - 2019/6/21
N2 - Gamma frequency oscillations (?, 30?100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain ? oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on ? oscillations. We explored the effects of multiple intracellular kinases on MA modulation of ? induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on ? oscillations, whereas none of them affected baseline ? strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of ? oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
AB - Gamma frequency oscillations (?, 30?100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain ? oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on ? oscillations. We explored the effects of multiple intracellular kinases on MA modulation of ? induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on ? oscillations, whereas none of them affected baseline ? strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of ? oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.
UR - https://www.open-access.bcu.ac.uk/7878/
U2 - 10.3389/fncel.2019.00277/full
DO - 10.3389/fncel.2019.00277/full
M3 - Article
VL - 13
JO - Frontiers in Cellular Neurosceince
JF - Frontiers in Cellular Neurosceince
IS - 277
ER -