TY - JOUR
T1 - The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
AU - Trigg, Ricky M.
AU - Lee, Liam C.
AU - Prokoph, Nina
AU - Jahangiri, Leila
AU - Reynolds, C. Patrick
AU - Amos Burke, G. A.
AU - Probst, Nicola A.
AU - Han, Miaojun
AU - Matthews, Jamie D.
AU - Kai Lim, Hong
AU - Manners, Eleanor
AU - Martinez, Sonia
AU - Pastor, Joaquin
AU - Blanco-Aparicio, Carmen
AU - Merkel, Olaf
AU - de los Fayos Alonso, Ines Garces
AU - Kodajova, Petra
AU - Tangermann, Simone
AU - Högler, Sandra
AU - Luo, Ji
AU - Kenner, Lukas
AU - Turner, Suzanne D.
N1 - Funding Information:
4Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 5Department of Experimental Pathology and Laboratory Animal Pathology, Institute of Clinical Pathology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria. 6Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna 1210, Austria. 7Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA. 8Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Boltzmanngasse 20, Medical University of Vienna, Vienna 1090, Austria. 9Present address: Functional Genomics, Medicinal Science & Technology, GlaxoSmithKline, Stevenage SG1 2NY, UK. 10Present address: Amgen, Thousand Oaks, CA 91320, USA. 11Present address: OncoSec, San Diego, CA 92121, USA. 12These authors contributed equally: Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Lukas Kenner, Suzanne D. Turner. *email: [email protected]
Funding Information:
This research is supported with funding from Children with Cancer UK (CWCUK; 16-209) awarded to S.D.T. and L.C.L., R.M.T. was supported by the CWCUK grant and L.C.L. was in receipt of a Cancer Research UK Cambridge Centre Paediatric Programme PhD studentship. N.P., L.J., O.M., I.G.F.A., L.K. and S.D.T. are supported by a European Union Horizon 2020 Marie Skłodowska–Curie Innovative Training Networks (ITN-ETN) Grant, Grant No.: 675712. N.A.P. was supported by ERASMUS+. We are grateful to AstraZeneca for providing us with AZD1208 and Inflection Biosciences for providing us with PIMi. We thank Isaia Barbieri for critical suggestions on the manuscript, BBSCR NIHR Cell phenotyping hub for flow cytometry expertise, the Bauer Core Facility at Harvard University for sequencing, and Liew Jun Mun and Stephen P. Ducray for technical assistance. Funding for the COG/ALSF Childhood Cancer Repository was provided by Alex’s Lemonade Stand Foundation.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
UR - http://www.scopus.com/inward/record.url?scp=85075611555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075611555&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13315-x
DO - 10.1038/s41467-019-13315-x
M3 - Article
C2 - 31780656
AN - SCOPUS:85075611555
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5428
ER -