Transcriptional modulation of human endogenous retroviruses in primary CD4+ T cells following vorinostat treatment

Cory H. White; Nadejda Beliakova-Bethell; Steven M. Lada; Michael S. Breen; Tara P. Hurst; Celsa A. Spina; Douglas D. Richman; John Frater; Gkikas Magiorkinis; Christopher H. Woelk

doi:10.3389/fimmu.2018.00603

Transcriptional modulation of human endogenous retroviruses in primary CD4⁺ T cells following vorinostat treatment

Cory H. White, Nadejda Beliakova-Bethell, Steven M. Lada, Michael S. Breen, Tara P. Hurst, Celsa A. Spina, Douglas D. Richman, John Frater, Gkikas Magiorkinis, Christopher H. Woelk^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (SciVal)

Original language	English
Article number	603
Journal	Frontiers in Immunology
Volume	9
Issue number	APR
DOIs	https://doi.org/10.3389/fimmu.2018.00603
Publication status	Published (VoR) - 12 Apr 2018

Funding

We acknowledge support from the IRIDIS 4 High Performance Computing Facility and associated support services at the University of Southampton, the Collaboratory of AIDS Researchers for Eradication (CARE), the Bioinformatics Core at the University of Southampton, and the Genomics and Sequencing Core at the UCSD Center for AIDS Research. This work was performed with the support of the UCSD Center for AIDS Research from the National Institutes of Health (NIH) to DR (P30 AI36214); the U.S. Department of Veterans Affairs grant (K2BX002731) to NBB; the James B. Pendleton Charitable Trust; as well as other NIH grants to DR (the CARE Martin Delaney Collaboratory U19 AI096113) and to CWo (AI104282). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords

Histone deacetylase inhibitor
Human endogenous retroviruses
Long terminal repeat
Primary CD4 T cells
Total RNA-Seq

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10.3389/fimmu.2018.00603

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title = "Transcriptional modulation of human endogenous retroviruses in primary CD4+ T cells following vorinostat treatment",

keywords = "Histone deacetylase inhibitor, Human endogenous retroviruses, Long terminal repeat, Primary CD4 T cells, Total RNA-Seq",

author = "White, \{Cory H.\} and Nadejda Beliakova-Bethell and Lada, \{Steven M.\} and Breen, \{Michael S.\} and Hurst, \{Tara P.\} and Spina, \{Celsa A.\} and Richman, \{Douglas D.\} and John Frater and Gkikas Magiorkinis and Woelk, \{Christopher H.\}",

note = "Funding Information: We acknowledge support from the IRIDIS 4 High Performance Computing Facility and associated support services at the University of Southampton, the Collaboratory of AIDS Researchers for Eradication (CARE), the Bioinformatics Core at the University of Southampton, and the Genomics and Sequencing Core at the UCSD Center for AIDS Research. This work was performed with the support of the UCSD Center for AIDS Research from the National Institutes of Health (NIH) to DR (P30 AI36214); the U.S. Department of Veterans Affairs grant (K2BX002731) to NBB; the James B. Pendleton Charitable Trust; as well as other NIH grants to DR (the CARE Martin Delaney Collaboratory U19 AI096113) and to CWo (AI104282). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 White, Beliakova-Bethell, Lada, Breen, Hurst, Spina, Richman, Frater, Magiorkinis and Woelk.",

year = "2018",

month = apr,

day = "12",

doi = "10.3389/fimmu.2018.00603",

language = "English",

volume = "9",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media",

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TY - JOUR

T1 - Transcriptional modulation of human endogenous retroviruses in primary CD4+ T cells following vorinostat treatment

AU - White, Cory H.

AU - Beliakova-Bethell, Nadejda

AU - Lada, Steven M.

AU - Breen, Michael S.

AU - Hurst, Tara P.

AU - Spina, Celsa A.

AU - Richman, Douglas D.

AU - Frater, John

AU - Magiorkinis, Gkikas

AU - Woelk, Christopher H.

N1 - Funding Information: We acknowledge support from the IRIDIS 4 High Performance Computing Facility and associated support services at the University of Southampton, the Collaboratory of AIDS Researchers for Eradication (CARE), the Bioinformatics Core at the University of Southampton, and the Genomics and Sequencing Core at the UCSD Center for AIDS Research. This work was performed with the support of the UCSD Center for AIDS Research from the National Institutes of Health (NIH) to DR (P30 AI36214); the U.S. Department of Veterans Affairs grant (K2BX002731) to NBB; the James B. Pendleton Charitable Trust; as well as other NIH grants to DR (the CARE Martin Delaney Collaboratory U19 AI096113) and to CWo (AI104282). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018 White, Beliakova-Bethell, Lada, Breen, Hurst, Spina, Richman, Frater, Magiorkinis and Woelk.

PY - 2018/4/12

Y1 - 2018/4/12

KW - Histone deacetylase inhibitor

KW - Human endogenous retroviruses

KW - Long terminal repeat

KW - Primary CD4 T cells

KW - Total RNA-Seq

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DO - 10.3389/fimmu.2018.00603

M3 - Article

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SN - 1664-3224

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - APR

M1 - 603

ER -

Transcriptional modulation of human endogenous retroviruses in primary CD4⁺ T cells following vorinostat treatment

Funding

Keywords

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